A study on the in vitro degradation of poly（L-lactide）/chitosan microspheres scaffolds-中国Betway体育网页登陆

摘要 Recentresearchshowsthattheadditionofchitosanmicrospheres（CMs）topoly（L-lactide）（PLLA）canresultinacompositescaffoldmaterialwithimprovedbiocompatibilityandmechanicalpropertiesfortissueengineeringapplications.However,researchregardingtheinfluenceofCMsonscaffolddegradationisabsentintheliterature.ThispaperpresentsastudyontheinvitrodegradationofscaffoldsmadefromPLLAwithCMs.Inthisstudy,thePLLA/CMsscaffoldswitha25%ratioofCMstoPLLAwereimmersedinphosphate-bufferedsaline（PBS）solutionat37℃for8weeks.Theinvitrodegradationofthescaffoldswasinvestigatedusingmicro-computedtomography（μCT）,weightlossanalysis,Ramanspectroscopy,anddifferentialscanningcalorimetry（DSC）.MicrostructurechangesduringdegradationweremonitoredusingμCT.TheμCTresultswereconsistentwiththeresultsobtainedfromRamanspectraandDSCanalysis,whichreflectedthataddingCMsintoPLLAcandecreasethedegradationratecomparedwithpurePLLAscaffolds.TheresultssuggestthatPLLA/CMsscaffolddegradationcanberegulatedandcontrolledtomeetrequirementsimposedagiventissueengineeringapplication.

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A study on the in vitro degradation of poly（L-lactide）/chitosan microspheres scaffolds

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