简介：Inthispaper,theoceanacousticchannelisconsideredasatime-variantchannel.Inordertoanalysetheconjointtime-shift-fre-quency-delaydistributionorthefadingandspreadstatisticalcharacteristicsofthechannel.TheTDWVS(TwoDimensionalWigner-VilleSpectrum)ofthetime-variantchannelisdefined.TherelationbetweentheWVS(Wigner-VilleSpectrum)oftheinputandtheoutputofthechannelisdiscussedandsomeexamplesforthespecificchannelareshown.Finally,theapplicationsonthedetectionofsignalsinnoiseusingtheWVSandTDWVSaregivenandtheadvantageisobvious,whenthedetectedsignalislinearfrequency-modulationsignal.

简介：CT120,anovelmembrane-associatedgeneimplicatedinlungcarcinogenesis,waspreviouslyidentifiedfromchromosome17pl3.3locus,ahotmutationspotinvolvedinhumanmalignancies.Inthepresentstudy,wefurtherdeterminedthatCT120ectopicexpressioncouldpromotecellproliferationactivityofNIH3T3cellsusingMTSassay,andmonitoredthedownstreameffectsofCT120inNIH3T3cellswithAtlasmousecDNAexpressionarrays.Among588knowngenes,133geneswerefoundtobeupregulatedordownregulatedbyCT120.Twomajorsignalingpathwaysinvolvedincellproliferation,cellsurvivalandanti-apoptosiswereoverexpressedandactivatedinresponsetoCT120:OneistheRaf/MEK/ErksignalcascadesandtheotheristhePI3K/Aktsignalcascades,suggestingthatCT120mightcontribute,atleastinpart,totheconstitutivelyactivationofErkandAktinhumanlungcanercells.Inaddition,sometumormetastasisassociatedgenescathepsinB,cathepsinD,cathepsinL,MMP-2/TIMP-2werealsoupregulatedbyCT120,uponwhichCT120mightbeinvolvedintumorinvasivenessandmetastasis.Inaddition,CT120mightplayanimportantroleintumorprogressionthroughmodulatingtheexpressionofsomecandidate“LungTumorProgression”genesincludingB-Raf,Rab-2,BAX,BAG-1,YB-1,andCdc42.

简介：与关于遥感图象的分类质量的研究的开发，研究人员们认为不确定性是影响分类质量的主要因素。这研究提出一条途径到不确定性表示，它从二个方面被开发：形式化的描述和全面评估。首先，我们用模糊监视途径完成分类，作为对分类不确定性的形式化的描述拿它。然后，我们为分类不确定性评估介绍一个混合的熵模型，它能满足几不确定性的全面思考的要求，当与对每个象素的错误率的不同贡献的完整的考虑从象素规模构造评估索引时。最后，一个应用程序例子将被学习检验新方法。结果证明评估结果充分反映分类质量，当与常规评估相比从单一的不确定性和范畴构造模型的方法可伸缩时。

简介：3、RGIS的提出GIS(以上海城市航空遥感信息系统为例）若是一种以遥感（RS）信息为主的地理信息系统,若同时又强调要以地形图作为所有GIS基础地理信息图,上海城市发展1999.12ISSN1009-2870上海城市发展信息研究中心

简介：北京2014年9月11日电/--服务于全球工程师的分销商Electrocomponentsplc（LSE：ECM）集团旗下的贸易品牌RSComponents（RS）公司宣布将独家销售一款新的视觉传感器检查套件,用户可以通过该产品进行多应用领域的快速零件检查和质量控制,例如,分拣系统、装配检验、对齐和旋转校验、尺寸和形状检查等。

简介：本文扼要的分析了RS触发器的不定区域

简介：ASTONMARTIN作为一个传奇式的英伦品牌,一直定义在极端奢华的性能跑车行列,在007电影外似乎就没有机会窥其身影。日前,随着新款概念车的亮相,整个品牌产品线层次得以更细腻地划分,600匹马力猛兽的亮相只是为了试探众人的口味。

简介：摘要：本文介绍了RS-2100加氢脱硫催化剂在青岛石化公司100万吨/年汽柴油加氢装置上的工业应用情况，包括装置开工、催化剂的工业应用及装置标定情况。工业应用结果表明，RS-2100催化剂具有良好的深度加氢脱硫、脱氮活性，可在相对缓和的操作条件下生产出硫含量低于350μg/g的低硫柴油产品。

简介：无

简介：AbstractBackground:Hyperbaric oxygen treatment (HBOT) has been demonstrated to influence the keloid recurrence rate after surgery and to relieve keloid symptoms and other pathological processes in keloids. To explore the mechanism of the effect of HBOT on keloids, tumor immunegeneexpression and immune cell infiltration were studied in this work.Methods:From February 2021 to April 2021, HBOT was carried out on keloid patients four times before surgery. Keloid tissue samples were collected and divided into an HBOT group (keloid with HBOT before surgery [HK] group, n = 6) and a non-HBOT group (K group, n = 6). Tumorgeneexpression was analyzed with an Oncomine Immune Response Research Assay kit. Data were mined with R package. The differentially expressed genes between the groups were compared. Hub genes between the groups were determined and verified with Quantitative Real-time PCR. Immune cell infiltration was analyzed based on CIBERSORT deconvolution algorithm analysis ofgeneexpression and verified with immunohistochemistry (IHC).Results:Inflammatory cell infiltration was reduced in the HK group. There were 178 upregulated genes and 217 downregulated genes. Ten hub genes were identified, including Integrin Subunit Alpha M (ITGAM), interleukin (IL)-4, IL-6, IL-2, Protein Tyrosine Phosphatase Receptor Type C (PTPRC), CD86, transforming growth factor (TGF), CD80, CTLA4, and IL-10. CD80, ITGAM, IL-4, and PTPRC with significantly downregulated expression were identified. IL-10 and IL-2 were upregulated in the HK group but without a significant difference. Infiltration differences of CD8 lymphocyte T cells, CD4 lymphocyte T-activated memory cells, and dendritic resting cells were identified withgeneCIBERSORT deconvolution algorithm analysis. Infiltration levels of CD4 lymphocyte T cell in the HK group were significantly higher than those of the K group in IHC verification.Conclusion:HBOT affected tumorgeneexpression and immune cell infiltration in keloids. CD4 lymphocyte T cell, especially activated memory CD4+T, might be the key regulatory immune cell, and its relatedgeneexpression needs further study.

简介：ＳＴＵＤＹＯＮＭＥＴＡＳＴＡＳＩＳＡＳＳＯＣＩＡＴＥＤＧＥＮＥＳＣＲＥＥＮＥＤＢＹＭＯＮＯＣＬＯＮＡＬＡＮＴＩＢＯＤＹＨＩＬＱｉＴｅｎｇｐｉｎｇ齐藤平；Ｚｈａｎｇｐｅｉｊｉ张沛基；ＷｅｉＳｈｕｇｕａｎｇ魏曙光；ＣｈｅｎＤｏｎｇ陈东；ＬｉＲｅｎ李仁；Ｗ...

简介：Object:ToidentifytranscriptvariantsandexpressionpatternsofporcineMitf.Materialsandmethods:ApairwiseBLASTsearchatNCBIdatabasewasperformedtodeducethestructureofporcineMitfgene.Subsequently,50RACEandfluorescentquantitativeRT-PCRwereusedtoanalyzetheexpressionpatternofporcineMitfindifferenttissues.Results:FourtranscriptvariantsofporcineMitf,MITF-A,MITF-H,MITF-MandMITF-SUSwereidentified,allsharinghighhomologywiththoseinhumans,exceptMitf-SUS.Conclusion:ThesequenceofporcineMitfappearhighlyhomologoustohumanMITF.However,only4transcriptvariantsofporcineMitfwereidentifiedintheseminipigs,lessthanthe9transcriptvariantsinhumanMITF.

简介：

简介：WeclonedcDNAsforXenopusaldolasesA,BandC.Thesethreealdolasegenesarelocalizedondifferentchromosomesasasinglecopygene.Intheadult,thealdolaseAgeneisexpressedextensivelyinmuscletissues,whereasthealdolaseBgeneisexpressedstronglyinkidney,liver,stomachandintestine,whilethealdolaseCgeneisexpressedinbrain,heartandovary.InoocytesaldolaseAandCmRNAs,butnotaldolaseBmRNA,areextensivelytranscribed.Thus,aldolaseAandCmRNAs,butnotBmRNA,occurabundantlyineggsasmaternalmRNAs,andstrongexpressionofaldolaseBmRNAisseenonlyafterthelateneurulastage.WeconcludethataldolaseAandCmRNAsaremajoraldolasemRNAsinearlystagesofXenopusembryogenesiswhichproceedsutilizingyolkastheonlyenergysource,aldolaseBmRNA,ontheotherhand,isexpressedonlylaterindevelopmentintissueswhicharerequiredfordietaryfructosemetabolism.WealsoisolatedtheXenopusaldolaseCgenomicgene(ca.12kb)andfoundthatitspromoter(ca.2kb)containsregionsnecessaryfortissue-specificexpressionandalsoaGCrichregionwhichisessentialforbasaltranscriptionalactivity.

简介：Cowdensyndrome(CS),anautosomaldominantdisorder,isoneofaspectrumofclinicaldisordersthathavebeenlinkedtogermlinemutationsinthephosphataseandtensinhomolog(PTEN)gene.Although70-80%ofpatientswithCShaveanidentifiablegermlinePTENmutation,theclinicaldiagnosispresentsmanychallengesbecauseofthephenotypicandgenotypicvariations.Inthepresentstudy,wesequencedtheexonsandthepromoterofPTENgene,mutationsandvariationsinthepromoterandexonswereidentified,andaPTENproteinexpressionnegativeregionwasdeterminedbyimmunohistochemistry(IHC).Inconclusion,anovelpromotermutationwefoundinPTENgenemayturnoffPTENproteinexpressionoccasionally,leadingtothedisorderofPTENanduntypicalCSmanifestations.

简介：AbstractObjective:To investigate the effects of vitrification on the expression of the imprintedgeneSnrpn in neonatal placental tissue.Methods:Neonatal placental tissue was collected from women with natural pregnancy (control group) and from women in assisted reproductive technology (ART) pregnancy group, following fresh and vitrified embryo transfer (fresh group and vitrified group, respectively). Snrpn mRNA expression and SNRPN protein levels in placental tissue from these three groups were assessed by real-time reverse transcription polymerase chain reaction and Western blot, respectively. DNA methylation in the Snrpn promoter region was analyzed by bisulfite-pyrosequencing.Results:The expression of Snrpn mRNA and SNRPN protein was found to be higher in placental tissue from the fresh and vitrified ART groups, compared to the control group. There was no significant difference in SNRPNgeneor protein expression between the fresh and vitrified groups. DNA methylation at the Snrpn promoter region was not significantly different between these three groups.Conclusions:Human ART may alter the transcriptional expression and protein levels of the imprintedgeneSnrpn. However, compared to other ART methods, vitrification may not aggravate or reduce this effect. Moreover, the altered expression of Snrpn is likely not directly related to DNA methylation of the Snrpn promoter region.

简介：

简介：43个米饭变化的DNA碎片被放大，11份教材基于植物的抵抗基因类似物(RGA)设计了，并且变化的强风抵抗被接种与33识别从云南省收集的Magnaporthegrisea孤立，中国。聚类结果与0.6117的一个关联系数揭示了在强风抵抗和DNA乐队之间的重要关联(α=0.01)，显示抵抗分析基于接种与那基于聚类分析的RGA-PCR与一致。关联系数，然而，从0.1701～0.535取决于教材。五份教材，S1/AS3，S1INV/S2INV，XLRRFor/XLRR加快，Pto-Kin1IN/Pto-Kin2在，和NLRRFor/NLRR加快可能被申请在他们的乐队数字和多型性的考虑的强风抵抗鉴定，和他们有强风抵抗的关联系数是0.5305，0.4898，0.4059，0.3719和0.3524分别地。而且，除了二个高度易受影响的变化，CO39和Lijiangxintuanheigu的indica和装饰用的梨树米饭，能被11份教材很好分类。

简介：Deareditor,Itiswithgreatinterestthatwereadthearticle“Relationshipofcalcitoningene-relatedpeptidewithdiseaseprogressionandprognosisofpatientswithseveretraumaticbraininjury”(Chenetal.,2018).Inthisstudy,theauthorsevaluated121patientswhoweredividedintomild/moderatetraumaticbraininjury(TBI)(n=61),severeTBI(n=35)andcontrol(n=25)groups,andmeasuredserumlevelsofcalcitoningene-relatedpeptide(CGRP)andserumendothelin-1(ET-1).TheyfoundthatlowlevelsofCGRPandhighlevelsofET-1wereassociatedwithhighmortalityat6months.IdentificationofmorphologicalabnormalitiesonCTscansisveryimportantforevaluatingpatientswithTBIbecausedifferentdiagnosesaremadebasedondifferentimagingfindings(Maasetal.,2005).

简介：Objective:Toinvestigatetherelationshipbetweengenemutationandpathologicaltypeoflungcancer,inspectandverifytheconsistencybetweenhomologousgenesmutationinvariouspathologictype.Methods:CombinedwiththeCOSMICandUniProtdatabase,weobtainedthereportedoverallbig-samplemutationdataoflungcancerandtheproteinsequencesofthetop20mutatedgenes,respectively.Analyzethedataandclustertheproteinsequencesandthendeducethehomologousgene.Ultimately,analyzethemutationsofdifferentpathologicaltypesofhomologousgenes.Results:TP53(32.32%)hasthehighestmutationrateinlungcancer,followedbyEGFR(29.12%).Thecopynumbervariability(CNV)ofgenes:KRAS,LRP1B,CDKN2A,KMT2C,FAT1,PIK3CA,RB1,ERBB4,GRIN2AandKDRbetweeneachpathologicaltypeisstaticallysignificant(P<0.05).ThegenedifferentialexpressionratebetweenadenocarcinomaandsquamouscarcinomaofgeneTP53,KRAS,LRP1B,CDKN2A,STK11,FAT4,KMT2D,NFE2L2,KEAP1,PIK3CA,RB1,ERBB4,SMARCA4andKDRarestatisticallysignificant(P<0.05).ThesimilarityoftheproteinsequenceofEGFRandERBB4canreach93%,andFAT4andFAT1are81%.Forsmallcellcarcinoma,there’snodifferenceinCNVbetweenthetwogroupsofhomologousgenes,andnodifferencebetweenFAT4andFAT1inadenocarcinoma.Conclusion:TheCNVandgeneexpressionoflungcancer-associatedgenesarerelevanttopathologictypes.GFRandERBB4arehomologous,FAT4andFAT1arealsoamongthetop20mutationgenes.Additionally,there’snodifferenceinCNVbetweenthetwogroupsofsmallcellcarcinoma,whichisthesamebetweenFAT4andFAT1inadenocarcinoma.