简介：AbstractBackground:The hypocaloric diets improve glycemic status in obese individuals, but the response to hypocaloric diets in fat mass and obesity-associatedgene(FTO)-rs9939609genevariantis unknown. This systematic review and meta-analysis aimed to assess thegene-diet interaction of FTO-rs9939609genevariantand hypocaloric diets on glycemic control in overweight and obese adults.Methods:Cochrane Central Register of Controlled Trials, PubMed, ISI Web of Science, Embase, Scopus, and Google scholar were searched up to December 2018, for relevant clinical trials. Mean changes in fasting blood sugar (FBS), serum insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) were extracted.Results:The pooled analysis of nine studies showed that there was no significant difference between AA/AT and TT genotypes in FBS (weighted mean difference [WMD] = 0.01, 95% confidence interval [CI]: -1.08, 1.10, P = 0.984) and serum insulin (WMD = 0.20, 95% CI: -0.85, 1.26; P = 0.707) after intervention hypocaloric diets. The overweight/obese participants in AA/AT group showed the greatest reduction in HOMA-IR compared with TT genotype following intervention, and this difference was not statistically significant (WMD = -0.38, 95% CI: -0.94, 0.16, P = 0.167).Conclusion:This meta-analysis suggests that there was no significant difference between AA/AT and TT genotypes of FTO-rs9939609on FBS, serum insulin level, and insulin resistance in response to hypocaloric diets.

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简介：AbstractPurpose:Evidence suggests that the oxytocin receptor (OXTR)genemay be involved in the psychopathology of posttraumatic stress disorder (PTSD). This study aimed to investigate the effects of OXTRrs53576 genotype on PTSD symptoms introduced in the Diagnostic and Statistical Manual, Fifth Edition (DSM-5).Methods:This study was a cross-sectional study conducted among 1140 adults who had personally experienced the Wenchuan earthquake. PTSD symptoms were measured with the PTSD checklist for DSM-5. A custom-by-design 2 × 48-Plex SNPscanTM Kit were used to determine the OXTRrs53576. Multiple regression models were used to analyze the independent and interactive effects of OXTRrs53576 genotype and earthquake exposure on the severity of total PTSD symptoms and different dimensions of PTSD symptoms.Results:The results revealed that thers53576 genotype could significantly predict PTSD symptoms (β = 0.055, p = 0.045). Further analysis showed that thers53576 genotype was only significantly associated with dysphoric arousal symptoms of PTSD (β = 0.080, p = 0.005). Thers53576 genotype × earthquake exposure interaction had no significant effect on different symptom clusters (p > 0.05).Conclusion:This study showed that thers53576 genotype was only associated with the dysphoric arousal symptoms but not with other symptom clusters of PTSD. These findings support the role of the OXTR on the psychopathology of PTSD and help us to understand the genetic basis of PTSD.

简介：Anadaptivealgorithmforsolvinglargenonsymmetriclinearsystemsispresentedinthispaper.ThenewalgorithmcombinespolynomialpreconditioningtechniquewiththeCGNRmethod.Residualpolynomialisusedinthepreconditioningtoestimatetheeigenvaluesofthes.p.d.matrixArA,andtheresidualpolynomialisgeneratedfromseveralstepsofCGNRbyrecurrence.Thealgorithmisadaptiveduringitsimplementation.Therobustnessismaintained,andtheiterationconvergenceisspeededup.Twonumericaltestresultsarealsoreported.

简介：Inthepresentpaper,wedealwithChlodowskytypegeneralizationoftheBaskakovoperators,specialcaseoftheseoperatorsincludesChlodowskytypeMeyer–KonigandZelleroperators(see[21]).WiththehelpofBohman-Korovkintheorem,weobtainsomeapproximationpropertiesfortheseoperators.Wegiveamodificationoftheoperatorsinthespaceofdifferentiablefunctionsandwealsopresentexamplesofgraphsforapproximation.Finally,weapplytheseoperatorstothesolutionofthedifferentialequation.

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简介：摘要：本文简述了RS232、RS422与RS485的由来、接口标准及网络安装注意要点，分析了其接地问题及瞬态保护。

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简介：InthispaperthegeneralizedBianchi’sidentitiesforthevariantconstrainedsystem(GBIVOS)withnon-invariantactionintegralandconstraintconditionswasderived,andthestrongandweakconservationlawsforsuchsystemwasdeduced.ThepreliminaryapplicationsoftheGBIVCStothecaseforsomemodelsoffieldtheorieswasgiven.TheDiracconstraintofsuchsystemwasdiscussed.

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简介：Inthepresentpaper,weintroduceSzász-Durrmeyer-BézieroperatorsMn,o(f,x),whichgeneralizethetionsofboundedvariation.OurresultextendsandimprovesthatofSahaiandPrasad[9]andGuptaandPant[3].

简介：对于生活在中国的宝马M和奔驰AMG战车来说，你们即将面对三足鼎立的战局。因为奥迪RS来了！2012款奥迪RS5高性能轿跑车将在今秋正式登陆中国，北京车展便是它初展雄威的地方。

简介：RS-232、RS-485都是串行数据接口标准.由于它们的接口电路简单,通用性比较好,所以在控制领域有着广泛的应用.RS-232和RS-485有着各自的优缺点:RS-232是低速率串行单端标准,采取不平衡传输方式(即所谓单端通信),收、发端的数据信号是相对于信号地的电平而言,其共模抑制能力差,传送距离短,其为点对点的通信方式;RS-485采用平衡传输方式,可以实现多点通信,由于采用了有别于RS-232电平方式的差分方式,使得在通信速率、抗干扰和传输距离方面都有较大的改善.

简介：PlantWRKYtranscriptionfactors(TFs)constituteoneofthelargestfamiliesofproteinsinvolvedinbioticandabioticstressresponses.TheseTFshaveaconserved60aminoacidWRKYdomainattheN-terminalandazincfingermotifattheC-terminal.ToexaminetherelevanceofOsWRKY72inimpartingsalinitystresstolerance,twoindicaricegenotypes,Rasi(tolerantgenotype)andTellahamsa(susceptiblegenotype),wereused.InRasiseedlingsat12hunder100mmol/LNaClstress,OsWRKY72expressionwasup-regulated,whereasinTellahamsa,itwashighlyup-regulatedatlethalstress.Full-lengthOsWRKY72cDNAwasclonedfromthesetworicegenotypesforfurtheranalysis.Weidentifiedavariant,termedasOsWRKY72bthatcarriesanadditionalsequenceof111bpwithintheWRKYdomain.ExpressionofOsWRKY72bwashigherundersalinitystressinRasithaninTellahamsa.DisorderpredictionofOsWRKY72bshowedthattheadditionalsequenceintheWRKYdomainisorderedtherebymaintainingthetertiarystructurethatmightinteractwiththemajorgrooveofDNA.PredictionofphosphorylationsitesinOsWRKY72bindicatedthatafewserineresiduescouldbethepotentialphosphorylationsites.Inthisstudy,wefirstlyreportedaOsWRKY72variantthatcouldhavearoleinabioticstressresponses.

简介：ObjectiveThestudyistoidentifythecarrierrateofcommondeafnessmutationinChinesepregnantwomenviadetectingdeafnessgenemutationswithgenechip.MethodsThepregnantwomeninobstetricclinicwithouthearingimpairmentandhearingdisordersfamilyhistorywereselected.Theinformedconsentwassigned.PeripheralbloodwastakentoextractgenomicDNA.Applicationofgeneticdeafnessgenechipfordetecting9mutationalhotspotofthemostcommon4Chinesedeafnessgenes,namelyGJB2(35delG,176del16bp,235delC,299delAT),GJB3(C538T),SLC26A4(IVS72A>G,A2168G)andmitochondrialDNA12SrRNA(A1555G,C1494T).Furthergenetictestingwereprovidedtothespousesandnewbornsofthescreenedcarriers.ResultsPeripheralbloodof430pregnantwomenweredetected,detectionofdeafnessgenemutationcarriersin24cases(4.2%),including13casesoftheGJB2heterozygousmutation,3casesofSLC26A4heterozygousmutation,1casesofGJB3heterozygousmutation,and1caseofmitochondrial12SrRNAmutation.18spousesand17newbornstookfurthergenetictests,and6newbornsinheritedthemutationfromtheirmother.ConclusionThecommondeafnessgenesmutationhasahighcarrierrateinpregnantwomengroup,235delCandIVS7-2A>Gheterozygousmutationsarecommon.

简介：AbstractOmicron (B.1.1.529), the fifthvariantof concern (VOC) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was firstly identified in November 2021 in South Africa. Omicron contains far more genome mutations than any other VOCs ever found, raising significant concerns about its increased transmissibility and immune evasion. Here, we report the importation of the Omicronvariantinto Beijing, China, in December 2021. Full-length genome sequences of five imported strains were obtained, with their genetic features characterized. Each strain contained 57 to 61 nucleotide substitutions, 39 deletions, and 9 insertions in the genome. Thirty to thirty-two amino acid changes were found in the spike proteins of the five strains. The phylogenetic tree constructed by the maximum likelihood method showed that all five imported genomes belonged to Omicron (BA.1) (alias of B.1.1.529.1), which is leading to the current surge of coronavirus disease 2019 (COVID-19) cases worldwide. The globally increased COVID-19 cases driven by the Omicronvariantpose a significant challenge to disease prevention and control in China. Continuous viral genetic surveillance and increased testing among international travellers are required to contain this highly contagiousvariant.

简介：AbstractCOVID-19 has been a global health concern since 2019 until date. Global concerted efforts to combat this pandemic has resulted in a number of vaccines distributed across the globe. Although the presence of these vaccines produced quick interventions, dynamic mutation in the causal virus and the continuous evolution of new stains that defy available vaccines has given rise to pertinent questions. The most recent emergence of a new COVID-19 virusvariant(omicron), the rapid spread and overwhelming rate of morbidity and mortality has reopened these questions for debate. This commentary summarizes major view on these questions and concludes that multiple approach including social behavioural measures, vaccination and antiviral drug would speed up elimination process.

简介：Itisaveryimportantandcomplicatedissuetochooseandconfirmtechnologyschemes,whichisalsoacomplicatedsystemengineeringthathascharacteristicssuchasmulti-factor,multi-levelandmulti-goaletc.Soweneedtooptimizeandappraiseitwiththemethodofmulti-goalandmulti-principle.Basedondiscussingtherelationbetweentechnologyandeconomy,thispaperputsforwardthefactorswhichshouldbeconsideredtoappraisetechnologyschemessynthetically,thoughtsandmethodsofvariantvalue-weighted,andbringsforwardanewsyntheticalappraisalmodelwhichcanappraisetechnologyschemesobjectivelyandcomprehensively.

简介：BymeansofthefrozentimeapproachandtheKroneckerproduct,twocriteriaofasymptoticstabilityarederivedforthelinear,timevariantdynamicsystemswitheithershorttimedelaysorwithweakfeedbackinvolvingarbitrarytimedelays,respectively.Itisfoundthattheasymptoticstabilityoftheseretardeddy-nainicsystemsisgovernedbythemaximalandminimalsingularvaluesofthecoeffi-cientmatricesandtheirtimederivatives.

简介：Inthispaperanewmethodtorealizerationalgeneralizedtransferfunctionsoflinearshift-variantdigitalfiltersthroughstatefeedbackispresentedInsomepracticalapplicationstherequiredcharacteristicsofthefilterchangeslowly.Underthesecircumstances,theproposedmethodisveryeffectiveandtheresultingfilterstructureissimple.Anumericalexampleisprovidedtoshowtheperformanceofthemethod.