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简介：Cerebralischemianotonlycausespathologicalchangesintheischemicareasbutalsoinducesaseriesofsecondarychangesinmoredistalbrainregions(suchasthecontralateralcerebralhemisphere).Theimpactofsupratentoriallesions,whicharethemostcommontypeoflesion,onthecontralateralcerebellumhasbeenstudiedinpatientsbypositronemissiontomography,singlephotonemissioncomputedtomography,magneticresonanceimaginganddiffusiontensorimaging.Inthepresentstudy,weinvestigatedmetabolitechangesinthecontralateralcerebralhemisphereaftersupratentorialunilateralischemiausingnuclearmagneticresonancespectroscopy-basedmetabonomics.Thepermanentmiddlecerebralarteryocclusionmodelofischemicstrokewasestablishedinrats.Ratswererandomlydividedintothemiddlecerebralarteryocclusion1-,3-,9-and24-hourgroupsandtheshamgroup.~1Hnuclearmagneticresonancespectroscopywasusedtodetectmetabolitesintheleftandrightcerebralhemispheres.Comparedwiththeshamgroup,theconcentrationsoflactate,alanine,γ-aminobutyricacid,cholineandglycineintheischemiccerebralhemispherewereincreasedintheacutestage,whiletheconcentrationsofN-acetylaspartate,creatinine,glutamateandaspartateweredecreased.Thisdemonstratesthatthereisanupregulationofanaerobicglycolysis(shownbytheincreaseinlactate),aperturbationofcholinemetabolism(suggestedbytheincreaseincholine),neuronalcelldamage(shownbythedecreaseinN-acetylaspartate)andneurotransmitterimbalance(evidencedbytheincreaseinγ-aminobutyricacidandglycineandbythedecreaseinglutamateandaspartate)intheacutestageofcerebralischemia.Inthecontralateralhemisphere,theconcentrationsoflactate,alanine,glycine,cholineandaspartatewereincreased,whiletheconcentrationsofγ-aminobutyricacid,glutamateandcreatinineweredecreased.Thissuggeststhatthereisadifferenceinthemetabolitechangesinducedbyischemicinjuryinthecontral

简介：目的：探讨局灶性脑缺血再灌注大鼠病理学改变以及针刺的干预作用。方法：采用线栓法建立缺血再灌注模型，应用“醒脑开窍”针法并通过电镜与光镜来观察缺血侧大脑皮层形态结构的变化。结果：脑缺血再灌注可引发大鼠脑神经元、胶质细胞、毛细血管等结构损伤，针剌可改善脑缺血周围区超微结构损伤。并且发现在3h时间点给予针刺干预较其他时间点理想。结论：针刺对局灶性脑缺血再灌注大鼠脑神经细胞超微结构损伤具有保护作用。在3h内给予针刺干预可以收到满意的效果。

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简介：ThirtyWistarratswererandomlyandevenlydividedintocontrolgroup,cerebralischemiagroupandischemia+electroacupuncture(EA)group.Thebilateralcommoncarotidarterieswereoccludedtoinduceacutecerebralischemia.Nitricoxide(NO)andendothelin(ET)contentsinthecerebraltissuesandbloodweremeasuredundernormalcondition,immediatelyafterischemiaandfollowingEA.ResultsshowedthatafteracutecerebralischemiaNOandETcontentsinthecerebraltissuesincreasedsignificantly(P<0.01)whileserumETincreasedandserumNOloweredobviously(P<0.05).FollowingEAofBaihui(GV20)andDazhui(GV14),bothNOandETincerebraltissuesandserumturnedtonormalbasically.ItshowedthatEAcouldprotectthecerebraltissuesfrominjuryinducedbyischemia,NOandETmightparticipateinthemodulationprocessofEA.

简介：Objective:Toinvestigatetheunderlyingneurobiologicalmechanismoftheprotectiveeffectofelectroacupuncture(EA)duringcerebralischemia-reperfusion(CI-R).Methods:Inthefirstpartofthestudy,15SDratswereevenlyrandomizedintocontrolgroup,CI-R-48hmodelgroupandCI-R-48h+EAgroup.ThecorticalapoptosisandexpressionofBcl-2andBaxproteinsineachgroupweredetectedbyflowcytometer(FCM).Inthesecondpartofthestudy,75SDratswereevenlyrandomizedintocontrol,CI-R-3min,CI-R-3min+EA,CI-R-48handCI-R-48h+EAgroups.Corticalnorepinephrine(NE)concentrationwasdetectedbyfluorescencespectrometer.CI-Rmodelwasestablishedbyocclusionofthebilateralcommoncarotidarteriesandreperfusion.EA(4～16Hz,1～3V)wasappliedafterreperfusionrespectively.Results:Inthefirstpartofthisstudy,resultsindicatedthatthenumberoftheapoptoticneuronsandtheapoptosisrateofCI-R-48hgroupweresignificantlyhigherthanthoseofcontrolgroup;whilecomparisonbetweenCI-R-48h+EAandCI-R-48hgroupsshowedthatthenumberoftheapoptoticneuronsandtheapoptosisrateoftheformergroupweresignificantlylowerthanthoseofthelatergroup(P<0.05).Incomparisonwithcontrolgroup,afterCI-48h,Baxexpressionwasup-regulatedsignificantlyandBcl-2down-regulatedmarkedly(P<0.05).ComparisonbetweenCI-R-48handCI-R-48h+EAgroupindicatedthatBaxexpressionofthelatergroupwassignificantlylowerthanthatoftheformergroup,whileBcl-2expressionofCI-R-48h+EAgroupwassignificantlyhigherthanthatofCI-R-48hgroup(P<0.05),suggestingthatEAcouldreverseCIinducedreactionsofthesetwoindexes.Inthesecondpartofthestudy,incomparisonwithcontrolgroup,NEconcentrationincerebralcortexofCI-R-3mingroupincreasedsignificantly(P<0.05);whileNEcontentofCI-R-3min+EAgroupwassignificantlylowerthanthatofCI-R-3mingroup(P<0.05).NosignificantdifferencewasfoundbetweenCI-R-3mingroupandcontrolgroupincorticalNEl

简介：Objective:Toobservetheeffectofacupunctureonimagesinautismchildren.Methods:Atotalof27casesofautismchildrenweresubjectedintothisstudy.ByusingaSPECT,thecerebralimageswerecollectedbeforeandafteracupuncturetreatmentandanalyzedaccordingtotherecommendedmethodsinforassessingthestateofbloodflow,radioactivityquantitydistributionandradioactivitycountinbilateralhemispheres.'JIN'sthree-needling'wasemployed.Theacupuncturetreatmentwasgivenonceeveryotherday,with4monthsbeingatherapeuticcourseandanintervalofonemonthbetweentwocourses.Results:Afteracupuncturetreatment,ofthe22cases,20hadremarkableimprovementand2hadimprovementincerebralbloodflow,withthetotaleffectiverateofimprovingcerebralbloodflowbeing90.8%.Beforethetreatmentthereweresignificantdifferencesbetweentheleftandrightcerebrum(P<0.001),andbetweentheleftandrightfrontallobesinradioactiveareas(P<0.01);however,aftertreatment,nodifferenceswerefoundbetweenthem(P>0.05).Aftertreatment,theradioactivitycountinthewholebraindecreasedsignificantlyincomparisonwiththatofpretreatment(P<0.01).Itindicatestheimprovementofcerebralbloodflowandcellularmetabolismafterthetreatment.Conclusion:Acupumctureconsignificantlyimprovecerebralbloodflowinautismchildren.

简介：Objectives:Toexploretheeffectofacupunctureoncerebralinfarctioninratsandtotryprovidingsomeexperimentalparametersforclinicalpractice.Methods:27healthyWistarratswererandomlydividedintopseudo-operation(n=10),model(n=8)andacupuncture(n=9)groups.Neuro-functionaldefectscoring,apoptosisofsinglebrainsliceandthenumberofbcl-2immuno-reaction(IR)-positiveneuronsinCA1areaofthehippocampuswereusedastheindexestoinvestigatethepossiblemechanismsofacupunctureof'NieSanZhen'(needlingthreeacupointsinthetemporalregion)and'SiShenZhen'(needlingfouracupointsintheocciputregion)intreatingratswithcerebralinfarction.Results:Thereexistedsignificantdifferencesbetweenacupuncturegroupandmodelgroupinimprovingneurologicfunctionalactivities,inhibitingapoptosisofthebraincellsandincreasingbcl-2IR-positiveneuronsinthehippocampalCA1area(P＜0.01).Conclusion:Acupuncturetherapycanimprovecerebralinfarctionintheratbysuppressingapoptosisandup-regulationofthebcl-2IR-positiveneuronexpression.

简介：Objective:Toimprovethediagnosisandtreatmentofseverecerebralfatembolism(SCFE).Methods:ThedataofninepatientswithSCFEwereretrospectivelyanalyzed.Themanifestationsofthecentralnervesystem,respiratorysystemandhemorrhagewererecorded,atthesametime,accessoryexaminationincludingarterialoxygen,fatmacroglobulesinvenousbloodandimageexaminationwasadapted.Thepatientsweretreatedwithexopexy,pharmocotherapyandoxygentherapy.Results:Twooftheninepatientsdiedofseverecomplications,theothersevenrecoveredwithoutseveresequela.Conclusions:GurdstandardshouldbeimprovedforearlydiagnosisofSCFE.Ifsverecomplicationscanbeprevented,patientswhoreceiveearlytreatmentwillhavefavourableprognosis.

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简介：BACKGROUND:Calciumion(Ca2+)overloadplaysanimportantroleincerebralischemia/reperfusioninjury.Anisodamine,atypeofalkaloid,canprotectthemyocardiumfromischemiaandreperfusioninjurybyinhibitingintracellularcalcium[Ca2+]ioverload.OBJECTIVE:Toinvestigateeffectsofanisodamineon[Ca2+]iconcentrationandcortexultrastructurefol-lowingacutecerebralischemia/reperfusioninrabbits.DESIGN,TIMEANDSETTING:RandomizedandcontrolledtrialwasperformedattheDepartmentofEmergency,TongjiHospital,TongjiMedicalCollegeofHuazhongUniversityofScienceandTechnologyfromSeptembertoDecember2006.MATERIALS:Fortyhealthyrabbitswereusedtoestablishmodelsofacutecerebralischemia/reperfusion.AnisodaminewasprovidedbyLianyungangDongfengPharmaceuticalFactory;Fura-2waspurchasedfromNanjingJianchengBioengineeringInstitute;dual-wavelengthfluorescentspectrophotometrysystemandDM-300softwarewereprovidedbyBio-Rad,USA;OPTON-EM10CtransmissionelectronmicroscopewasproductofSiemens,Germany.METHODS:Fortyrabbitswererandomlydividedintothefollowinggroups:shamoperation,ischemia,ischemia/reperfusion,andanisodamine,withtenrabbitsineachgroup.Modelsofcompletecerebralischemiainjurywereestablished.Inaddition,bloodwascollectedfromthefemoralarteryofratsintheischemia/reperfusionandanisodaminegroupstoinducehypotensionandestablishreperfusioninjurymodels.Thebilateralcommoncarotidarteryclampwasremovedfromtheanisodaminegroup20minutesafterischemia,andanisodamine(10mg/kgbodymass)wasinjectedviathefemoralvein.Rabbitsintheshamoperationgroupunderwentonlyvenouscannulation.MAINOUTCOMEMEASURES:[Ca2+]iconcentrationwasdeterminedusingadual-wavelengthfluorescentspectrophotometrysystem,andcorticalultrastructurewasobservedfollowinguranyl-leadcitratestaining.RESULTS:Thelevelsof[Ca2+]iintheischemiaandischemia/reperfusiongroupsweresignificantlyin-creased,c

简介：AbstractBackground:Dense exudate during the calcification ofcerebralcysticercosis in basal subarachnoid space was easy to be misdiagnosed as subarachnoid hemorrhage (SAH); clinical evaluation and MRI can help differentiate SAH from pseudo-SAH.Case presentation:A case of ventricular expansion accompanied by high-density shadows in cisterna circinata cerebri was taken to the hospital for treatment due to sudden faint. This patient was diagnosed as subarachnoid hemorrhage according to computed tomography (CT) in another hospital. We believe that the high density in cisterna circinata cerebri was misdiagnosed as subarachnoid hemorrhage (SAH) 1 year ago. The main etiology of SAH is aneurysm; non-aneurysmal SAH associated withcerebralcysticercosis is extremely rare. Only 5 patients have been reported.Conclusion:This case indicated that although the specificity of CT for SAH is very high, the physicians should be aware of rare false positive findings, called pseudo-SAH.

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简介：目的将为服的梗塞续发症观察温暖挖出的刺破方法的临床的效果。有在有包括标准的一致的服的梗塞续发症的六十个病人随机被划分成一个治疗组和控制的方法组织，在每个组的30个盒子。控制组被给西方的药的基本治疗。治疗组被增加，针灸治疗在西方的药的治疗之上基于。在由健康的国家研究所的治疗摸规模(NIHSS)前后，病人的神经病学的缺点被估计。结果显著药品率是83.3%，全部的有效的率在治疗组是93.3%，对56.7%和70.0%处于在二个组之间的显著药品率和全部的有效的率与统计差别在控制组织(P<0.05)。在治疗以后，NIHSS分数在两个组减少了(P<0.01或P<0.05)，并且差别是统计的在二个组之间重要(P<0.01)。结论温暖挖出的刺破方法比在服的梗塞续发症的治疗的西方的药的单个治疗好。

简介：Objective:Toobservethetherapeuticeffectofoculo-acupuncturetherapyinthetreatmentofcerebralinfarctioninducedhemiplegia.Methods:58casesofstrokepatientswererandomlydividedintotreatmentgroup(n=30)andcontrolgroup(n=28).Intreatmentgroup,onthebasisofmedicationplusrehabilitationtreatment,patientsvoluntarilyacceptedoculo-acupuncturetherapy(acupunctureofUpper-JiaoAreaandLower-JiaoArea).Incontrolgroup,patientsonlyacceptedmedicationandrehabilitationtreatment.ThetherapeuticeffectwasevaluatedwithBrunstrom's6-stagesAssessingMethod.Results:After24sessionsoftreatment,theratiosofthediseasedlimbsreachingstageⅥandmoreinfunctionalactivityinthepatientsoftreatmentgroupincreasedfrom16.7%(upper-limb)and20.0%(lower-limb)beforetreatmentto70.0%and90.0%respectively;whileincontrolgroup,thoseratiosoftheupperandlowerlimbsincreasedfrom10.7%and28.6%beforetreatmentto39.2%and60.7%separately.Therewasasignificantdifferencebetweentwogroupsinthetherapeuticeffect(P＜0.05).Conclusion:Oculo-acupunctureplusmedicationissuperiortosimplemedicationtreatmentinimprovingfunctionalactivityofthehemiplegiclimbs.

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简介：1定义及抢救意义心脏的有效收缩停止，引起全身组织缺血、缺氧，继之呼吸停止及意识丧失。心肺复苏(CPR)的目的是为了保证脑的复苏，因此，CPR不如CPCR更为确切。

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简介：BACKGROUND:Stellateganglionblock(SGB)playsaprotectiveroleonthebrain,buttheprecisemecha-nismofactionisnotclear.OBJECTIVE:TosimulateSGBbytransectionofthecervicalsympathetictrunk(TCST)andtoinvestigatetheTCSTeffectsonchangesincerebralinfarctvolumeandoxygenfreeradicallevelsinratswithfocalcere-bralischemia/reperfusioninjury.DESIGN,TIMEANDSETTING:AcompleterandomizedcontrolanimalexperimentwasperformedattheInstituteofNeurologicalDiseasesofTaiheHospital,YunyangMedicalCollegefromFebruarytoDecember2005.MATERIALS:Atotalof101healthyWistarrats,weighing280–320g,ofbothgenders,aged17–18weeks,wereusedinthisstudy.2,3,5-triphenyltetrazoliumchloride(TTC)waspurchasedfromChangshaHongyuanBiologicalCompany.Superoxidedismutase(SOD),malondialdehyde(MDA)andnitricoxide(NO)assaykitswereprovidedbyNanjingJianchengBioengineeringInstitute.METHODS:RatswererandomlydividedintoaTCSTgroup,amodelgroupandashamoperationgroup.Successfulmodelswereincludedinthefinalanalysis,withatleast20ratsineachgroup.AfterTCST,ratmodelsoffocalcerebralischemia/reperfusioninjurywereestablishedintheTCSTgroupbyreceivingmiddlecerebralarteryocclusion(MCAO)bytheintraluminalsuturemethodfor2hours,followedby24hoursofreperfusion.Ratmodelsoffocalcerebralischemia/reperfusioninjuryweremadeinthemodelgroup.Ratsintheshamoperationgroupunderwentexperimentalproceduresasforthemodelgroup,threadingdepthof10mm,andmiddlecerebralarterywasnotligated.MAINOUTCOMEMEASURES:BraintissuesectionsoftenratsfromeachgroupwereusedtomeasurecerebralinfarctvolumebyTTCstaining.BraintissuehomogenateofanothertenratsfromeachgroupwasusedtodetectSODactivities,MDAcontentsandNOlevels.Ratneurologicalfunctionwasassessedbyneu-robehavioralmeasures.RESULTS:CerebralinfarctvolumewasbiggerinthemodelgroupthanintheTCSTgr