Cardiac Connexin 43 and Ischemic Cardioprotection-中国Betway体育网页登陆

摘要 Theconnexin43(Cx43)proteins,whichisthepredominantproteinthatcanformgapjunctionsandnon-junctionalhemichannelsinventricularmyocardium,arecentraltothecardioprotectionaffordedbyischemicpreconditioning(IP)andmaybeischemicpostconditioning(PC)too.RecentstudiesshowedthatrecruitmentofCx43tothemitochondriainIPmightplayaroleintheproductionofreactiveoxygenspecies(ROS)thatmediatesIP.ThelocalizationofCx43atmitochondriaappearstobeimportantfortheachievedcardioprotectionandopensanewdoorforustorevealtheexactmechanismsofischemia/reperfusion(I/R)injuryandcardioprotection,anditmightbenewtargetsofpharmacologicalmodulatortoachievedcardioprotection.

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Cardiac Connexin 43 and Ischemic Cardioprotection

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