摘要
AbstractDiabetes mellitus and pancreatic ductal adenocarcinoma are two common diseases worldwidely which are both derived from different components of pancreas. The pancreatic and duodenal homeobox-1 (PDX1) is an essential transcription factor for the early development of pancreas that is required for the differentiation of all pancreatic cell lineages. Current evidence suggests an important role of PDX1 in both the origin and progression of pancreatic diseases. In this review, we discussed recent studies of PDX1 in diabetes mellitus and pancreatic cancer, and the therapeutic strategies derived from this transcription factor.
机构地区
Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China,Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China,Department of Forensic Science, School of Basic Medical Sciences, Central South University, Changsha, Hunan 410013, China.
出版日期
2020年08月10日（中国Betway体育网页登陆平台首次上网日期，不代表论文的发表时间）
