Bridging peripheral nerve defect with chitosan-collagen film-中国Betway体育网页登陆

摘要 Objective:Toseeknewmethodforthetreatmentofperipheralnerveinjury.Methods:Inratmodelwithsciaticnervedefect,chitosan-collagenfilmwassuturedintoconduittobridge5mm,10mmnervedefects.Ratsthatunderwentend-to-endanastomosisweretakenascontrols.Generalobservation,electrophysiologicalstudy,histologicalstudyandimageanalysiswereperformedat4,8,12weekspostoperatively.Results:In5mmnervedefects,thequalityofnerveregenerationwassimilartothatofthecontrolgroup.For10mmnervedefect,nerveregenerationwasinferiortothatofthecontrolgroup.Chitosan-collagenfilmobviouslydegradedat12weekspostoperatively.Conclusions:Chitosan-collagenfilmconduitcanbeusedtobridgeperipheralnervedefect.

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Bridging peripheral nerve defect with chitosan-collagen film

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