摘要
Objectives:Recentstudieshaveintroducedmiddleearvolume(MEV)asanoveldeterminantofperforation-inducedconductivehearingloss(CHL)inamechanismdrivenbytrans-tympanicmembranepressuredifferences.Theprimaryaimsofthispreliminaryreportareto:1)correlateCHLwithperforationsize;2)describetherelationshipbetweenCHLandMEV;and3)compareCHLacrossarangeofcholesteatomainvolvement.Design:Aretrospectivepilotstudywasperformedin31subjectswithaudiometryindicativeofconductivehearingloss,temporalboneCTscans,andnopriormiddleearsurgery.PerforationsizeandMEVwereanalyzedwithrespecttoCHLinacohortof10perforatedearswithnocholesteatoma.CHLswerecomparedin3groupsdefinedbyextentofcholesteatomainvolvement.Results:EarswithlargeandsmallperforationsshowedmeanABGvaluesof32.0±15.7dBand16.0±16.4dB,respectively.AdirectrelationshipwasobservedbetweenMEVandCHLforearswithlargeperforationsacrossallfrequencies,whereasthisrelationshipforsmallperforationswasfrequency-dependent.Finally,astatisticallysignificantincreaseinCHLwasfoundacrossearswithincreasingcholesteatomainvolvementat1000Hz(c2(2)9.786,p0.008),2000Hz(c2(2)8.455,p0.015),and4000Hz(c2(2)8.253,p0.016).Conclusions:Thesepilotdatasuggestthatgreaterperforation-inducedconductivehearinglossesmaybeassociatedwithlargerperforationsizesandcholesteatoma.ThecorrelationbetweenMEVandCHLmayrequireadditionalstudy.
出版日期
2017年03月13日（中国Betway体育网页登陆平台首次上网日期，不代表论文的发表时间）
