摘要
Introduction:Middleearvolume(MEV)isaclinicallyrelevantparameteracrossmiddleeardiseases.MEVvaluesbetweenthesetechniqueshaveneverbeforebeentestedforagreementinearswithperforatedtympanicmembranes(TMs).Methods:Middleearswereidentifiedfrom36patientsranging18e89yearsofagewithTMperforationswhounderwenttympanometryandtemporalbonecomputedtomography(CT)between2005and2015.MEVscalculatedbybothtympanometryandthree-dimensionalvolumereconstruction(3DVR)wereanalyzedforagreementusingBlandAltmanplots.Thedifferencesbetweentympanometricand3DVRMEVvaluesforeachgivenmiddleearwerecharacterizedacrossMEVquartiles(1?smallest;4?largest)andacrossincreasingstatesofmiddleeardiseaseusingKruskaleWallisandWilcoxontestingwithBonferronicorrection.Results:BlandAltmanplotsdemonstratedsignificantdisagreementbetweenMEVmeasurementtechniques.Differencesbetweentympanometric(T)and3DVRMEVvaluesweresignificantlygreaterwithincreasingaverage(i.e.(Tt3DVR)/2))MEVperlinearregression(p<0.0001).SignificancewasdemonstratedbetweenfourthandfirstaverageMEVquartiles(p?0.0024),fourthandsecondquartiles(p?0.0024),thirdandfirstquartiles(p?0.0048),andthirdandsecondquartiles(p?0.048).AbsoluteMEVdifferencewasnotsignificantlydifferentacrossvaryingstatesofmiddleeardisease(p?0.44).Conclusion:Statisticallyandclinicallysignificantdisagreementwasdemonstratedbetweentympanometricand3DVRMEVvalues.StudiesthatvaryinMEVestimationtechniquesmaybeexpectedtodemonstratesignificantlydifferentresults.ThesepreliminaryresultssuggestthatcliniciansshouldendeavortoseekfurtherconfirmationwheninterpretinghightympanometricMEVvalues.
出版日期
2017年02月12日（中国Betway体育网页登陆平台首次上网日期，不代表论文的发表时间）
