简介： <正> ONINTEGRATIVEGEOTECTONICSChenGuoda(ChangshaInstituteofGeotectonics,AcademiaSinica,410003,Hunan,China)XiangJixi(TheChineseAcademyofGeologicalSciences,Beijing,China)integrativegeotectonics,crustobodygeotectonics,multi-originedandpolygeneticcompoundresultantforcesystem,tectosphere,gradualchange,mutation,catastrophismBasedonhistoristic-causationistgeotectonicsproposedbyChenGuodain1992,theauthorsattempttofurtherextenditscontentsandranges,establishintegrativegeo-tectonicswithwiderangesandhighersynthesis.Integrativegeotectonicsisdefinedasadisci-plinetostudyverysyntheticallythewholehistoryandcausationisticrelationsofformationandevolutionoftheglobaltectonics(includingthecrustalanddeepteetosphericstructures)withthecomprehensiveanalysismethod.Itisalsocalledas"crustobodygeotectonics"foritsmaingeotectonicelementiscrustobody.Itscharacteristicsare:(1)regardingtheinternalandexter-naldynamic

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简介：Tomeettherequirementsfortheaerodynamicperformanceandthrustforcedemandedinhypersonicmissions,theintegrationdesignoffuselageandenginemustbeconsideredforhypersonicvehiclewithascramjetengine.Theconfigurationofwaveriderisatypicalhypersonicvehicleshape,whosefore-bodycancompresstheflowinadvanceandprovideuniformflowfortheairintake,andwhoseaft-bodyisusedasanexpansionsurfaceofnozzle.Inthepresentpaper,anengineeringmethodisappliedtodefinetotalaerodynamiccharacteristicsofanapproximatewaveriderconfiguration.Afinitevolumemethodbasedonthecenterofgridisalsoemployedtonumericallyinvestigatetheoutflowpassthesameconfiguration.Theflowfielddetailsandtheaerodynamicchanacteristicsatgivenconditionsareobtained.Theevaluationforthisconfigurationmaybeusedasaguideforthehypersonicvehicleexperiment.

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简介：Interestingclassificationsofbasinogenesisandbasinswereproposedbymanyscientists.Theyclassifiedbasinogenesisandbasinsmainlyfromasingleangle,eitherfromahistoricalangleorfromadynamicangle.Inordertomorecomprehensivelyunderstandthemformoreeffectivelyguidingprospectingandexplo-ration,theauthorintegratesthetwomethodsofanalysiswitheachotherandproposesanintegrativeclassification.Accordingtothehistorical-dynamicintegrativeclassification,basinogenesisandbasinscanbe_di-videdintothreetypes:oceaniccrusttype,embryo—continental(transitional)crusttypeandcontinentalcrusttype.Oceaniccrusttypecanbesubdividedintomobileregiontype(mainlytensional)andstableregiontype.Embryo—continentaltypeincludespre-geosynclinaltype(divisibleintoseveralmobileregiontypesandstableregiontypeswithtensionaltypepredominatingamongmobileregiontypes)andear-ly-geosynclinaltype(mainlytensional).Continentalcrusttypeincludeslategeosynclinal(fo

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简介：AbstractBackground:The global prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing. The pathogenesis of NAFLD is multifaceted, and the underlying mechanisms are elusive. We conducted data mining analysis to gain a better insight into the disease and to identify the hub genes associated with the progression of NAFLD.Methods:The dataset GSE49541, containing the profile of 40 samples representing mild stages of NAFLD and 32 samples representing advanced stages of NAFLD, was acquired from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were identified using the R programming language. The Database for Annotation, Visualization and Integrated Discovery (DAVID) online tool and Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) database were used to perform the enrichment analysis and construct protein-protein interaction (PPI) networks, respectively. Subsequently, transcription factor networks and key modules were identified. The hub genes were validated in a mice model of high fat diet (HFD)-induced NAFLD and in cultured HepG2 cells by real-time quantitative PCR.Results:Based on the GSE49541 dataset, 57 DEGs were selected and enriched in chemokine activity and cellular component, including the extracellular region. Twelve transcription factors associated with DEGs were indicated from PPI analysis. Upregulated expression of five hub genes (SOX9, CCL20, CXCL1, CD24, and CHST4), which were identified from the dataset, was also observed in the livers of HFD-induced NAFLD mice and in HepG2 cells exposed to palmitic acid or advanced glycation end products.Conclusion:The hub genes SOX9, CCL20, CXCL1, CD24, and CHST4 are involved in the aggravation of NAFLD. Our results offer new insights into the underlying mechanism of NAFLD progression.

简介：Theoilpanusedinearengineisoneoftheimportantstructurepartsinthecar,whichis,ingeneral,deepdrawnanddifficulttofrom.Thedeep-drawingprocessesoftheoilpanusedintheenginefor'SmallFlag'CaroflheFirstAutomobileManufactoryisanalyzedbyusingtheintegrativeCAD/CAE/CAMtechniqueofstampingdie,ineludingtheCADsoftwareCATIAandthesheet-metalstampingCAEsoftwareKMASdevelopedindependently.ThroughananalysisofdiestructureandformabilityusingtheKMASsoft-ware,theprimarytwi-offdeep-drawinghassuccessfullybeenchangedtotheone-offdeep-drawing,solvingthekeyteehniealdifficultiesforthemanufactory.

简介：Purpose:Thisstudyaimstocompareadolescents’cardiometabolicriskscorethroughanintegrativeclassificationofphysicalactivity(PA),whichinvolvesthecombinationofmoderate-to-vigorousphysicalactivity(MVPA)andsedentarybehavior(SB).Methods:Across-sectionalstudyderivedfromtheHealthyLifestyleinEuropebyNutritioninAdolescenceCross-SectionalStudydatabase(2006-2008)wasconductedinadolescents(n=548;boys,47.3%;14.7±1.2years)from10Europeancities.MVPAandSBwereobjectivelymeasuredusingaccelerometry.Adolescentsweredividedinto4categoriesaccordingtoMVPA(meetingornotmeetingtheinternationalrecommendations)andthemedianofSBtime(aboveorbelowsex-andage-specificmedian)asfollows:High-SB&Inactive,Low-SB&Inactive,High-SB&Active,andLow-SB&Active.Aclusteredcardiometabolicriskscorewascomputedusingthehomeostaticmodelassessment,systolicbloodpressure,triglycerides,totalcholesterol/high-densitylipoproteincholesterol,sum4skinfolds,andcardiorespiratoryfitness(CRF).AnalysesofcovariancewereperformedtodiscerndifferencesoncardiometabolicriskscoresamongPAcategoriesandeachhealthcomponent.Results:ThecardiometabolicriskscorewaslowerinadolescentsmeetingtheMVPArecommendationandwithlesstimespentinSBincomparisontothehigh-SB&Inactivegroup(p<0.05).However,nodifferenceincardiometabolicriskscorewasestablishedbetweenHigh-SBorLow-SBgroupsininactiveadolescents.ItisimportanttonotethatCRFwastheonlyvariablethatshowedasignificantmodification(higher)whenchildrenwerecomparedfromthecategoryofphysicallyinactivewith"active"butnotfromhigh-tolow-SB.Conclusion:Beingphysicallyactiveisthemostsignificantandprotectiveoutcomeinadolescentstoreducecardiometabolicrisk.LowerSBdoesnotexhibitasignificantandextrabeneficialdifference.

简介：蜜蜂(Apismellifera)是有强壮的感觉能力和多样的行为的全部剧目的一只社会昆虫并且为学习学习和记忆的neurobiological基础作为一个好模型有机体被认出。在这研究，我们在microRNA(miRNA)和跟随用下一代的小RNA定序和介绍的Solexa/lllumina数字基因表示标签(DGE)的基于迷宫的视觉学习的送信人RNA(mRNA)分析了变化。为定序的小RNA，我们分别地从迷宫和控制组获得了13367770和13132655个干净标签。40差别的一个总数表示了已知的miRNAs在这二件样品之间被检测，并且所有他们在与控制组相比的迷宫组是起来调整的。为DGE，5681320和5939855个干净标签分别地从迷宫和控制组被检测。有388差别的一个总数表示了在这二件样品之间的基因，与起来调整的45基因和在迷宫组下面调整的343基因，与控制组相比。另外，10差别的表示层次表示了基因被量的反向的抄写聚合酶链反应(qRT-PCR)证实，他们中的八个的表示趋势与DGE结果一致，尽管变化的度在振幅是更低的。miRNA和mRNA表示的综合分析显示出那，在表示的40差别之中已知的miRNAs和388差别表示了基因，miRNA/mRNA的60pairs是在我们的现在的学习共同表示被识别。这些结果建议miRNA和mRNA可以在在蜜蜂学习和记忆的进程起一个枢轴的作用。我们的定序的数据为基于迷宫的视觉学习提供全面miRNA和基因表达式信息，它将便于蜜蜂学习和存储器的分子的机制的理解。

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