Leptin Signaling Protects NK Cells from Apoptosis During Development in Mouse Bone Marrow-中国Betway体育网页登陆

摘要增加的证据在有免疫力的反应显示leptin的一个角色，但是发信号的leptin是否涉及在骨头髓(BM)调整NK房间开发，仍然保持大部分不清楚。在这研究，我们在在prediabetic的缺乏的db/db老鼠上演的leptin受体的BM描绘了NK房间区别和成熟。尽管BM细胞质类似于控制值，NK房间的全部的数字严重地在变异的鼠标被减少。db/dbBM房间的流动cytometric分析揭示了在区别的各种各样的阶段开发NK房间的显著地减少的频率。显著地显示的BMdb/dbNK房间增加了apoptosis，但是维持了正常房间骑车地位和proliferative能力。而且，recombinantleptin能显著地在文化从野类型的老鼠提高NK房间的幸存。NK房间上的进一步的检查功能的活动证明db/dbNK房间与显著地增加的IL-10展出了正常内在的cytotoxicity生产。一起拿，我们的调查结果建议发信号的leptin经由在老鼠BM提高不成熟的NK房间的幸存调整NK房间开发。

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Leptin Signaling Protects NK Cells from Apoptosis During Development in Mouse Bone Marrow

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