摘要
[摘要 ] 目的 探讨高龄孕妇进行孕中期羊膜腔穿刺羊水细胞培养染色体核型分析，提高对胎儿畸形的预见性诊断分析结果。方法 随机选取该院 2017年 1月— 2018年 12月收治的 714例高龄孕妇给予羊膜腔穿刺前的检查及超声诊断，行羊膜腔穿刺抽取羊水的孕妇，进行羊水细胞培养，制备染色体标本，分析高龄孕妇羊水胎儿细胞的染色体核型和胎儿染色体异常情况。 结果 该研究选取的 714例高龄孕妇中染色体异常的分类有 21三体综合征、 18三体综合征、性染色体异常和其它的染色体异常。有 23例高龄孕妇的染色体出现异常，检出率为 3.22%； 714例高龄孕妇中 35～ 39岁占 450例，发现胎儿染色体异常例数 9例，检出率为 2..00%为最低； 44～ 46岁高龄孕妇占 31例，发现胎儿染色体异常例数为 3例，检出率为 9.68%为最高。结论 在产前对高龄孕妇进行羊膜腔穿刺羊水细胞染色体培养可以有效的检测胎儿的染色体异常情况，有效的对高龄孕妇分娩畸形胎儿进行预见性的诊断，明显降低新生儿的缺陷率。 [关键词 ] 羊膜腔穿刺术；羊水细胞染色体核型；高龄孕妇；畸形儿；预见性诊断；染色体异常 [Abstract] Objective To investigate the karyotype analysis of amniotic fluid cell culture by amniocentesis in the second trimester of pregnancy, and to improve the predictive diagnosis of fetal malformation. Methods a total of 714 elderly pregnant women admitted to our hospital from January 2017 to December 2018 were randomly selected for amniocentesis and ultrasound diagnosis before amniocentesis. Amniocentesis was performed to extract amniotic fluid from pregnant women. Amniotic fluid cells were cultured and chromosome samples were prepared to analyze the chromosome karyotype and fetal chromosome abnormality of amniotic fluid fetal cells of elderly pregnant women. Results 714 cases of chromosomal abnormalities were classified into 21 trisomy syndrome, 18 trisomy syndrome, sex chromosome abnormality and other chromosomal abnormalities. There are 23 cases of chromosomal abnormalities in the elderly pregnant women, the detection rate is 3.22%; among 714 cases of elderly pregnant women, 450 cases are 35-39 years old, 9 cases of fetal chromosomal abnormalities are found, the detection rate is 2.00%, which is the lowest; 31 cases are 44-46 years old, 3 cases of fetal chromosomal abnormalities are found, the detection rate is 9.68%. Conclusion amniocentesis and amniotic fluid cell chromosome culture can effectively detect the chromosomal abnormalities of the fetus, effectively diagnose the abnormal fetus in the delivery of the elderly pregnant women, and significantly reduce the defect rate of the newborn.
出版日期
2020年04月27日（中国Betway体育网页登陆平台首次上网日期，不代表论文的发表时间）
