Identifying G-protein Coupled Receptors Using Weighted Levenshtein Distance and Nearest Neighbor Method-中国Betway体育网页登陆

摘要 G-proteincoupledreceptors(GPCRs)areaclassofseven-helixtransmembraneproteinsthathavebeenusedinbioinformaticsasthetargetstofacilitatedrugdiscoveryforhumandiseases.AlthoughthousandsofGPCRsequenceshavebeencollected,theligandspecificityofmanyGPCRsisstillunknownandonlyonecrystalstructureoftherhodopsin-likefamilyhasbeensolved.Therefore,identifyingGPCRtypesonlyfromsequencedatahasbecomeanimportantresearchissue.Inthisstudy,anoveltechniqueforidentifyingGPCRtypesbasedontheweightedLevenshteindistancebetweentworeceptorsequencesandthenearestneighbormethod(NNM)isintroduced,whichcandealwithreceptorsequenceswithdifferentlengthsdirectly.Inourexperimentsforclassifyingfourclasses(acetylcholine,adrenoceptor,dopamine,andserotonin)oftherhodopsin-likefamilyofGPCRs,theerrorratesfromtheleave-one-outprocedureandtheleave-half-outprocedurewere0.62%and1.24%,respectively.Theseresultsarepriortothoseofthecovariantdiscriminantalgorithm,thesupportvectormachinemethod,andtheNNMwithEuclideandistance.

1Yun-Fei Wang Huan Chen Yan-Hong Zhou.Prediction and Classification of Human G-protein Coupled Receptors Based on Support Vector Machines.分子生物学,2005-04.
2Cui-Ping Guan Zhen-Ran Jiang Yan-Hong Zhou.Predicting the Coupling Specificity of G-protein Coupled Receptors to G-proteins by Support Vector Machines.分子生物学,2005-04.
3Thor C. Moiler;David Moreno-Delgado;Jean-Philippe Pin;Julie Kniazeff.Class C G protein-coupled receptors： reviving old couples with new partners.生物物理学,2017-04.
4Shu-xue Zou Yan-xin Huang Yan Wang Chun-guang Zhou.A Novel Method for Prediction of Protein Domain Using Distance-Based Maximal Entropy.生物工程,2008-03.
5XuehaiTan;PamSanders;JackBoladoJr.;MikeWhitneyt.Integration of G-Protein Coupled Receptor Signaling Pathways for Activation of a Transcription Factor （EGR-3）.分子生物学,2003-03.
6Zhi-HuaZhou YangYu.Adapt Bagging to Nearest Neighbor Classifiers.计算机科学与技术,2005-01.
7Wang Lu,He Huai-Wu,Xing Zhi-Qun,Tang Bo,Zhou Xiang.Lactate induces alternative polarization (M2) of macrophages under lipopolysaccharide stimulation in vitro through G-protein coupled receptor 81.医药卫生,2020-08.
8PAN Peng LU Yan-sheng.Monitoring nearest neighbor queries with cache strategies.物理,2007-04.
9Qing Wei Wenbin Zhou Guangzhen Hu Jiamian Wei Hongquan Yang Jirong Huang.Heterotrimeric G-protein is involved in phytochrome A-mediated cell death of Arabidopsis hypocotyls.细胞生物学,2008-09.
10Zeshui XU;Jian CHEN.ORDERED WEIGHTED DISTANCE MEASURE.系统科学,2008-04.

Identifying G-protein Coupled Receptors Using Weighted Levenshtein Distance and Nearest Neighbor Method

来源期刊

相关推荐

同分类资源更多

相关关键词