摘要
摘要目的探讨骨化三醇治疗血液透析患者继发性甲状旁腺功能亢进症的临床疗效,为骨化三醇的临床应用提供可靠依据;方法选取２０１３年０９月－２０１４年０９月我院收治的血液透析患者继发性甲状旁腺功能亢进症患者１３０例,随机分为对照组同研究组各６５例,对照组患者使用常规透析以及骨化三醇治疗,研究组患者使用低钙透析以及骨化三醇治疗,对比两组患者的治疗结果;结果两组患者的PTH水平(血甲状旁腺激素)在治疗的４、８以及１２周时均比治疗前出现显著下降(P＜０．０５),同时组间的同期比较,差异无统计学意义(P＞０．０５);对照组患者的血钙水平在治疗的第４、８以及１２周时均比治疗前明显上升((P＜０．０５),显著高于同期的研究组患者((P＜０．０５),联合组患者在治疗的第４、８以及１２周同治疗前对比,差异无统计学意义(P＞０．０５);两组患者的血磷水平在治疗的第４、８以及１２周均比治疗前出现显著下降(P＜０．０５),两组患者之间的同期比较,差异无统计学意义(P＞０．０５);结论骨化三醇联合低钙透析液治疗血液透析继发性甲状旁腺功能亢进症患者效果理想,临床上应当推广应用.关键词骨化三醇;血液透析;继发性;甲状旁腺功能亢进症;疗效Abstractobjectivetoexplorethetreatmentofcalcitriolhemodialysispatientswithsecondaryparathyroidfunctionalreadyclinicalcurativeeffect,provideareliablebasisfortheclinicalapplicationofcalcitriol;Methodsselectsep２０１３－sep２０１４ofourhospitalpatientswithhemodialysispatientswithsecondaryparaＧthyroidfunctionalready１３０cases,each６５caseswererandomlydividedintocontrolgroupandresearchgroup,controlgrouppatientsusingconventionaldialysisandcalcitrioltherapy,grouppatientswithlowcalciumdialysisandcalcitrioltreatment,comparedtwogroupsofpatientswiththetreatmentoftheresults;Resultstwogroupsofthepatient＇slevelofPTH(bloodparathyroidhormone)inthe４,８and１２weeksoftreatmentweresignificantlydeclinethanbeforetreatment(P＜０．０５),contemporarycomparisonbetweengroupsatthesametime,therewasnostatisticallysignificantdifference(P＞０．０５);Controlgrouppatientswithbloodcalciumlevelinthe４,８and１２weeksoftreatmentthanbeforetreatmentsignificantlyincreased(P＜０．０５),agroupofpatientsissignificantlyhigherthanthesameperiod((P＜０．０５),thejointgroupofpatientsinthetreatmentof４,８and１２weeksascomparedwithbeforetreatment,therewasnostatisticallysignifiＧcantdifference(P＞０．０５);thetwogroupsofpatients＇bloodphosphoruslevelsinthetreatmentof４,８and１２weeksweresignificantlydeclinethanbeforetreatＧment(P＜０．０５),betweenthetwogroupsofpatientsduringthesameperiod,therewasnostatisticallysignificantdifference(P＞０．０５);theconclusioncalcitriolcombinedtherapywithlowcalciumdialysatehemodialysispatientswithsecondaryparathyroidfunctionalreadyeffectisideal,shallbewidelyappliedclinically．KeywordsCalcitriol;Hemodialysis;Secondary;Parathyroidfunctionalready;Thecurativeeffect中图分类号R５８１文献标识码B文章编号１００８－６３１５(２０１５)１０－０３８２－０２
机构地区
孙艮１尹忠诚１陈其元２严钊２王和平２１．徐州医学院,南通大学附属建湖医院风湿肾脏科江苏徐州２２１０００;２．南通大学附属建湖医院风湿肾脏科建湖２２４７００作者简介:孙艮(１９８２－),女,主治医师,硕士研究生,主要从事肾内科血液净化治疗方面的研究.通讯作者:尹忠诚,男,硕士,教授,徐州医学院硕士生导师,主任医师,主要从事肾内科临床研究.
出版日期
2015年09月19日（中国Betway体育网页登陆平台首次上网日期，不代表论文的发表时间）
