Isolation and Characterization of 44.6 kDa Protein from Schistosoma japonicum Male Worm-中国Betway体育网页登陆

摘要 SolublemalewormantigenofSchistosomajaponicurn(Sj)wasinvestigatedfordevelopmentofnewvaccinecandidate.SDS--PAGEandWesternblottingwereperformedtocomparethedifferencebetweensolubleantigensfromwormsofdifferentsex.MicevaccinationwiththetestingpurifiedproteinwasfollowedbySjcereariaechallengetodetecttheprotectiveeffectagainstSj.Sixteenbandswereseenforthesolublemalewormantigenand12forthefemaleworm.Inaddition,adistinctbandof44.6kDafromthemalewormantigenwasobserved,anditsantigenicitywasdemonstratedbyWesternblotting.This44.6kDaproteincouldinducesignificantwormandeggreductionrateinmice(39.31%,41.98%,P<0.001).Inthisstudya44.6kDaproteinwasisolatedandpartiallycharacterized.Itsantigenicity,immunogenicityandthepartialimmuneprotectionsuggestitspotentialvaccinecandidteagainstSj.

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Isolation and Characterization of 44.6 kDa Protein from Schistosoma japonicum Male Worm

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