Relationship Between Apoptosis and PCNA Expression of Keratinocytes in Condylomata Acuminata

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    摘要 Objective:Toinvestigatetherelationshipbetweenapoptosisandproliferatingcellnuclearantigen(PCNA)expressionofkeratinocytesinCondylomataacuminata(CA).Methods:PCNAexpressionwasobservedbyimmunohistochemistrytechnique(ABCmethod)in51CAspecimensand18normalspecimensofforeskinorvaginalmucosae.55specimens(40intheCAgroupand15inthecontrolgroup)wererandomlysampledforinsitulabelingofapoptoticcellsusingtheTUNELmethod.Results:PositiveexpressionofPCNAinCAandcontrolgroupswere90.2%and77.8%,respectively,andtheproliferationindexinCAgroupwassignificantlyhigherthanthatinthecontrolgroup(P<0.001).Thepositiverateofapoptosiswas42.5%intheCAgroupand53.3%inthecontrolgroup,andtherewerenosignificantdifferencesintheapoptoticindexandapoptosis-proliferationratiobetweentwogroups(P>0.05).Theproliferationindexshowedasignificantnegativecorrelationwiththeapoptosis-proliferationratio(r=-0.62,P=0.01)intheCAgroup.Conclusion:ItissuggestedthattheproliferativeappearanceofCAcouldbeduetotheimbalancebetweencellgrowthandcelldeathwhichiscausedbymoreproliferationandlessapoptosisinkeratinocytes.
    机构地区 不详
    出版日期 2002年04月14日(中国Betway体育网页登陆平台首次上网日期,不代表论文的发表时间)
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