The Inhibitory Effects of Mouse ICOS-Ig Gene-Modified Mouse Dendritic Cells on T Cells-中国Betway体育网页登陆

摘要 Themainapproachtoreducegraftrejectionhasbeenfocusedonthedevelopmentofimmunosuppressiveagentsatpresent.Althoughthesestrategieshavereportedlyreducedgraftrejection,therehasbeenareciprocalincreaseinmoresevereimmunosuppressionandlethalinfections,aswellasseveresideeffects.BlockadeofcostimulatoryTcellresponsehasbeenprovedasoneofusefulstrategiestoreducegraftrejection.Furthermore,ithasbeenshownthatinfusionofdendriticcells(DCs)withapotentnegativeregulatoryabilityforTcellscouldprolongallograftsurvival.InthisstudymouseDCs(mDCs)weretransfectedwiththerecombinantplasmidpcDNA3.0containingmouseinduciblecostimulator-Ig(mICOS-Ig)cDNAbyelectroporation.ThetransientexpressionofmICOS-IginmDCcouldbedetectedbyELISAandSDS-PAGE.MouseICOS-IgfusionproteinexpressedinmDCandmICOS-Iggene-modifiedmDCcouldinhibitlymphocyteproliferationinmixedlymphocyteculture(MLC)invitro.Furthermore,mICOS-Iggene-modifiedmDCcouldinhibitlymphocyteproliferationinrecipientmice.TheseresultssuggestedthatmICOS-Iggene-modifiedmDCexertedinhibitoryeffectsonTcells,andmightbesuitablefortreatmentorpreventionofgraftrejectionandimmunopathologicdiseases.

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The Inhibitory Effects of Mouse ICOS-Ig Gene-Modified Mouse Dendritic Cells on T Cells

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