摘要
AIM:Toconductasystematicreviewofthepublishedepidemiologicalstudiesinvestigatingtheassociationoftheinteractionsbetweengenevariantsanddietaryintakewithgastriccancerrisk.METHODS:AliteraturesearchwasconductedinPubMed,EMBASE,andMEDLINEforarticlespublishedbetweenJanuary2000andJuly2013,and38studieswereidentified.Previousstudiesincludedvariousdietaryfactors(e.g.,fruitsandvegetables,soybeanproducts,salt,meat,andalcohol)andgeneticvariantsthatareinvolvedinvariousmetabolicpathways.RESULTS:Studiessuggestthatindividualswhocarryhigh-riskgeneticvariantsanddemonstrateparticulardietaryhabitsmayhaveanincreasedriskofgastriccancercomparedwiththosewhodonotcarryhigh-riskgeneticvariants.Distinctivedietarypatternsandvariationsinthefrequencyofgeneticvariantsmayexplainthehigherincidenceofgastriccancerinaparticularregion.However,mostpreviousstudieshavelimitations,suchasasmallsamplesizeandaretrospectivecasecontroldesign.Inaddition,paststudieshavebeenunabletoelucidatethespecificmechanismingene-dietinteractionassociatedwithgastriccarcinogenesis.CONCLUSION:Additionallargeprospectiveepidemiologicalandexperimentalstudiesarerequiredtoidentifythegene-dietmetabolicpathwaysrelatedtogastriccancersusceptibility.
出版日期
2014年12月22日（中国Betway体育网页登陆平台首次上网日期，不代表论文的发表时间）
