Transfusion of donor apoptotic splenocytes prolongs cardiac allograft survival in absence of immunosuppression-中国Betway体育网页登陆

摘要 <正> Althoughapoptosishasbeenrecentlydocumentedtotransmitimmunosuppressivesignals,theirsignificanceinallogeneictransplantationhasnotbeenreported.Inthepresentstudy,weinvestigatedtheinfluenceofdonorapoptoticsplenocytesonallograftsurvivalinaSDtoWistarratcardiactransplantmodel.Donorsplenocyteswereisolatedandirradiatedwithultraviolet(UV)toinduceapoptosisinvitro.5x107apoptotic,necroticoruntreateddonorspleencellsweretransfusedpreoperativelyandcardiacallogeneictransplantation

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Transfusion of donor apoptotic splenocytes prolongs cardiac allograft survival in absence of immunosuppression

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