摘要
AIM:Toestablishtheefficacyandsafetyofbimatoprost0.03%monotherapyinglaucomaandocularhypertension(OHT)patientswithinadequateintraocularpressure(IOP)oncurrenttherapy.METHODS:Pre-andpost-switchIOPswereanalyzedfor59consecutivepatientswhowereswitchedfromcurrenttherapytobimatoprostmonotherapybetween2011-2015.Demographicinformation,diagnosis,andanyadverseeventswererecorded.ChangeinIOPpost-preswitchwasanalyzedusinga2-sidedStudent'spairedt-testatthe5%significancelevel.RESULTS:TherewasastatisticallysignificantmeanreductioninIOPatthefirstfollowupvisit,whichwasmaintainedatsubsequentfollowupvisitsforpatientsregardlessofdiagnosis,orpre-switchtreatment(P<0.001).SubgroupanalysisalsodemonstratedastatisticallysignificantmeanreductioninIOPwhenlookingatOHTpatientsonly,aswellaspatientswithanydiagnosisswitchedfromlatanoprostmonotherapytobimatoprostmonotherapy(P<0.001).CONCLUSION:Thisisthelargestindependentdatasetwhichsupportsswitchingglaucomapatientswithpoorresponsetocurrenttreatmentontobimatoprostmonotherapybeforeconsideringotheradjuvantmedicalormoreinvasivetherapy.
出版日期
2017年08月18日（中国Betway体育网页登陆平台首次上网日期，不代表论文的发表时间）
