摘要
Purpose:Thepurposeofthisstudywastoinvestigatetheeffectsofobesityandhigh-intensityacuteexerciseonoxidant-antioxidantstatus,neurotrophicfactorexpression,andblood-brainbarrier(BBB)disruption.Methods:Twenty-fourhealthy,untrainedmen(12non-obese(mean14.9%bodyfat)and12obesesubjects(mean29.8%bodyfat))performed20minofcontinuoussubmaximalaerobicexerciseat85%maximaloxygenconsumption.Bloodsamplingwasperformedtoexaminetheoxidant-antioxidantstatus(reactiveoxygenspecies(ROS)andsuperoxidedismutase(SOD)),neurotrophicfactors(brain-derivedneurotrophicfactor(BDNF)andnervegrowthfactor(NGF)),andBBBdisruption(S100βandneuron-specificenolase)beforeandafteracuteexercise.Results:Theobesegroupshowedsignificantlyhigherpre-exerciseserumROSlevelsandsignificantlylowerpre-exerciseserumSODlevelsthanthenon-obesegroup(p<0.05).SerumROS,SOD,BDNF,NGF,andS100βlevelsweresignificantlyincreasedpost-exercisecomparedwithpre-exerciselevelsinboththenon-obeseandtheobesegroups(p<0.05).TheobesegroupshowedsignificantlyhigherserumROS,BDNF,NGF,andS100βlevelspost-exercisecomparedtothenon-obesegroup(p<0.05).Conclusion:OurstudysuggeststhatepisodicvigorousexercisecanincreaseoxidativestressandbloodneurotrophicfactorlevelsandinducedisruptionoftheBBB.Moreover,highlevelsofneurotrophicfactorinthebloodafterexerciseintheobesegroupmaybeduetoBBBdisruption,anditisassumedthatoxidativestresswasthemaincauseofthisBBBdisruption.
出版日期
2017年02月12日（中国Betway体育网页登陆平台首次上网日期，不代表论文的发表时间）
