摘要
Ras-associatedprotein-1(Rap1),asmallGTPaseintheRas-relatedproteinfamily,isanimportantregulatorofbasiccellularfunctions(e.g.,formationandcontrolofcelladhesionsandjunctions),cellularmigration,andpolarization.Throughitsinteractionwithotherproteins,Rap1playsmanyrolesduringcellinvasionandmetastasisindifferentcancers.ThebasicfunctionofRap1isstraightforward;itactsasaswitchduringcellularsignalingtransductionandregulatedbyitsbindingtoeitherguanosinetriphosphate(GTP)orguanosinediphosphate(GDP).However,itsremarkablydiversefunctionisrenderedbyitsinterplaywithalargenumberofdistinctRapguaninenucleotideexchangefactorsandRapGTPaseactivatingproteins.ThisreviewsummarizesthemechanismsbywhichRap1signalingcanregulatecellinvasionandmetastasis,focusingonitsrolesinintegrinandcadherinregulation,RhoGTPasecontrol,andmatrixmetalloproteinaseexpression.
出版日期
2017年01月11日（中国Betway体育网页登陆平台首次上网日期，不代表论文的发表时间）
