Association of genotypes of rs671 within ALDH2 with risk for gastric cardia adenocarcinoma in the Chinese Han population in high- and low-incidence areas-中国Betway体育网页登陆

摘要 Objective:Thisstudyaimedtodetermineifgastriccardiaadenocarcinoma(GCA)riskwasassociatedwiththelys(Aor*2)alleleatthers671(glu504lys)polymorphismwithinthealdehydedehydrogenase2(ALDH2)geneinaChineseHanpopulation.WealsoaimedtoinvestigateALDH2genotypicdistributionsbetweensubjectsfromhigh-andlow-incidenceareasforbothGCAandesophagealsquamouscellcarcinoma(ESCC).Methods:Wedesignedacase-controlstudyincluding2,686patientswithGCAand3,675controlsubjectsfromhigh-andlowincidenceareasforbothGCAandESCCinChina.TaqManallelediscriminationassaywasusedtogenotypethers671polymorphism.χ~2testandbinarylogisticregressionanalysiswereusedtoestimatetheoddsratiosforthedevelopmentofGCA,andmultivariateordinallogisticregressionwasusedtoanalyzeALDH2genotypicdistributionsamongdifferentgroups.Results:ComparedwithALDH2*1/*1homozygotes,ALDH2*1/*2andALDH2*2/*2carriersdidnotincreasetheriskforGCAintheChineseHanpopulation(P>0.05).Interestingly,theratioofhomozygousorheterozygousALDH2*2carriersinhighincidenceareasforbothGCAandESCCwaslowerthanthatinlow-incidenceareas(P<0.001).Conclusions:Genotypesofrs671atALDH2maynotincreaseGCAsusceptibilityinChineseHanpopulations.Inaddition,theALDH2genotypicdistributiondiffersbetweenChineseHanpopulationsfromhigh-andlow-incidenceareasforbothGCAandESCC.OurfindingsmayshedlightonthepossiblegeneticmechanismforthedramaticgeographicdifferencesofGCAoccurrenceinChina.

1YanLu;Yao-Chuxu;JingShen;Rong-BinYu;Ju-YinNiu;Jian-TaoGuo;XuHu;Hong-BingShen.E-cadherin gene C-160A promoter polymorphism and risk of non-cardia gastric cancer in a Chinese population.消化系统,2005-01.
2.high- and low-frequency probe tone tympanometry in chinese infants.耳鼻咽喉科,2007-01.
3Wen Dan,Zhou Xian-Liang,Du Xin,Dong Jian-Zeng,Ma Chang-Sheng.Association of interleukin-18 gene polymorphisms with Takayasu arteritis in a Chinese Han population.医药卫生,2020-10.
4WeiLiu;WeiminLi;NinglingSun.Association of HLA-DQ with Idiopathic Dilated Cardiomyopathy in a Northern Chinese Han Population.免疫学,2004-04.
5Hong-mei Mu;Chen Wu;Lian Zhang;Kai-feng Pan;Jun-ling Ma;Yang Zhang;Wen-qing Li;Hua-kang Tu;Hong-mei Zeng;Wei-dong Liu;Tong Zhou;Dong-xin Lin;Wei-cheng You.Genetic Polymorphism of PSCA and Risk of Advanced Precancerous Gastric Lesions in a Chinese Population.肿瘤,2010-02.
6Elmorshedy Hala,Bergquist Robert,Fayed Amel,Guirguis Wafaa,Abdel-Gawwad Ensaf,Eissa Safaa,Barakat Rashida.Elimination of schistosomiasis requires multifactorial diagnostics: evidence from high- and low-prevalence areas in the Nile Delta, Egypt.医药卫生,2020-08.
7Zhang Jun-Xian,Gong Wen-Ping,Zhu Dong-Lin,An Hui-Ru,Yang You-Rong,Liang Yan,Wang Jie,Tang Jing,Zhao Wei-guo,Wu Xue-Qiong.Mannose-binding lectin 2 gene polymorphisms and their association with tuberculosis in a Chinese population.医药卫生,2020-08.
8郭筱楠.乙醛脱氢酶2（ALDH2）基因研究进展.文化科学,2018-05.
9Xiaosong Qin,Peng Gao,Zhijie Zhang,Zhijian Bo,Shijun Li,Mei Yang,Jianhua Liu,Lina Wu,Ting Li,Zuowei Zhao,Yan Li,Haodong Bian,Yong Liu.A low-cost and high-efficiency 10-in-1 test for the PCR-based screening of SARS-CoV-2 infection in low-risk areas.医药卫生,2022-12.
10Zuowei Wang;Yiru Fang;Shaoping Zhang;Shunying Yu;Sanduo Jiang.Transmission of NOTCH4 and GRIK2 in a population of Han Chinese with schizophrenia and affective disorder.神经病学与精神病学,2008-03.

Association of genotypes of rs671 within ALDH2 with risk for gastric cardia adenocarcinoma in the Chinese Han population in high- and low-incidence areas

来源期刊

相关推荐

同分类资源更多

相关关键词