Evolving role of adiponectin in cancer-controversies and update-中国Betway体育网页登陆

摘要 Adiponectin(APN),anadipokineproducedbyadipocytes,hasbeenshowntohaveacriticalroleinthepathogenesisofobesityassociatedmalignancies.Throughitsreceptorinteractions,APNmayexertitsanti-carcinogeniceffectsincludingregulatingcellsurvival,apoptosisandmetastasisviaaplethoraofsignallingpathways.Despitethestrongevidencesupportingthisnotion,someworkmayindicateotherwise.Ourreviewaddressesallcontroversiescritically.Onthewhole,hypoadiponectinaemiaisassociatedwithincreasedriskofseveralmalignanciesandpoorprognosis.Inaddition,variousgeneticpolymorphismsmaypredisposeindividualstoincreasedriskofobesity-associatedmalignancies.WealsoprovideanupdatedsummaryontherapeuticinterventionstoincreaseAPNlevelsthatareofkeyinterestinthisfield.TodateeffortstomanipulateAPNlevelshavebeenpromising,butmuchworkremainstobedone.

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Evolving role of adiponectin in cancer-controversies and update

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