Changing paradigm of cancer therapy：precision medicine by next-generation sequencing-中国Betway体育网页登陆

摘要 Precisionmedicineaimstoidentifytherightdrug,fortherightpatient,attherightdose,attherighttime,whichisparticularlyimportantincancertherapy.Problemssuchasthevariabilityoftreatmentresponseandresistancetomedicationhavebeenlongstandingchallengesinoncology,especiallyfordevelopmentofnewmedications.Solidtumors,unlikehematologicmalignanciesorbraintumors,areremarkablydiverseintheircellularoriginsanddevelopmentaltiming.Theabilityofnext-generationsequencing(NGS)toanalyzethecomprehensivelandscapeofgeneticalterationsbringspromisestodiseasesthathaveahighlycomplexandheterogeneousgeneticcompositionsuchascancer.HereweprovideanoverviewofhowNGSisabletofacilitateprecisionmedicineandchangetheparadigmofcancertherapy,especiallyforsolidtumors,throughtechnicaladvancements,moleculardiagnosis,responsemonitoringandclinicaltrials.

1Xuchao Zhang;Zhiyong Liang;Shengyue Wang;Shun Lu;Yong Song;Ying Cheng;Jianming Ying;Weiping Liu;Yingyong Hou;Yangqiu Li;Yi Liu;Jun Hou;Xiufeng Liu;Jianyong Shao;Yanhong Tai;Zheng Wang;Li Fu;Hui Li;Xiaojun Zhou;Hua Bai;Mengzhao Wang;You Lu;Jinji Yang;Wenzhao Zhong;Qing Zhou;Xuening Yang;Jie Wang;Cheng Huang;Xiaoqing Liu;Xiaoyan Zhou;Shirong Zhang;Hongxia Tian;Yu Chen;Ruibao Ren;Ning Liao;Chunyan Wu;Zhongzheng Zhu;Hongming Pan;Yanhong Gu;Liwei Wang;Yunpeng Liu;Suzhan Zhang;Tianshu Liu;Gong Chen;Zhimin Shao;Binghe Xu;Qingyuan Zhang;Ruihua Xu;Lin Shen;Yilong Wu.Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology.肿瘤,2019-01.
2Christine Stanislaw;Yuan Xue;William R.Wilcox.Genetic evaluation and testing for hereditary forms of cancer in the era of next-generation sequencing.肿瘤,2016-01.
3Dahui Qin.Next-generation sequencing and its clinical application.肿瘤,2019-01.
4Alexander W Wyatt;Fan Mo;Yuzhuo Wang;Colin C Collins.The diverse heterogeneity of molecular alterations in prostate cancer identified through next-generation sequencing.泌尿科学,2013-03.
5Tongwu Zhang;Yingfeng Luo;Kan Liu;Linlin Pan;Bing Zhang;Jun Yu;Songnlan Hu.BIGpre： A Quality Assessment Package for Next-Generation Sequencing Data.分子生物学,2011-06.
6Samuel P.Strom.Current practices and guidelines for clinical next-generation sequencing oncology testing.肿瘤,2016-01.
7Wang Long,Jia Yi-Meng,Zuo Jing,Wang Yu-Dong,Fan Zhi-Song,Feng Li,Zhang Xue,Han Jing,Lyu Wen-Jing,Ni Zhi-Yu.Gene mutations of esophageal squamous cell carcinoma based on next-generation sequencing.医药卫生,2021-03.
8Li Aqian,Liu Lin,Wu Wei,Liu Yang,Huang Xiaoxia,Li Chuan,Liu Di,Li Jiandong,Wang Shiwen,Li Dexin,Liang Mifang.Molecular evolution and genetic diversity analysis of SFTS virus based on next-generation sequencing.医药卫生,2021-06.
9Li Shan,Jiang Wei,Peng Jin-Min,Du Bin,Weng Li.Herpes simplex virus associated sepsis in an immunocompetent adult: the value of next-generation sequencing.医药卫生,2020-08.
10Xue Gao;Pu Dai.Impact of next-generation sequencing on molecular diagnosis of inherited non-syndromic hearing loss.耳鼻咽喉科,2014-03.

Changing paradigm of cancer therapy：precision medicine by next-generation sequencing

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