Effects of apolipoprotein A polymorphism on plasma levels of lipids, progression of carotid atherosclerosis and response to statin therapy-中国Betway体育网页登陆

摘要 BackgroundStudieshaveshownthattheapo(a)gene(LPA)rs3798220polymorphismisassociatedwiththelevelsoflipidsandthecurativeeffectofstatintherapyforcarotidatherosclerosis(CAS).Whethercarriersofanapo(a)variantbenefitmorefromstatinremainsunclear.MethodsOnehundredandthreepatientswithCASwererecruitedfromApril2012toApril2013intheShundeFirstPeoplesHospitalAffiliatedtoSouthernMedicalUniversityinFoshan.Allpatientswereadministeredatorvastatin20mg/dandwerefollowed-upfor2years.withthelevelsofplasmaLp(a),totalcholesterol(TC),triglyceride(TG),highdensitylipoprotein(HDL),lowdensitylipoprotein(LDL).LPArs3798220genotypesofallpatientswereanalyzed.ResultsStatintreatmentsignificantlyreducedthelevelsofIMT,TC,TG,LDLandincreasedthelevelofHDL,butstatintreatmentdidnotreducethelevelofLp(a).AccordingtothecurativeeffectofstatintherapyinpatientswithCAS,rs3798220polymorphismhadacertaininfluenceonLDLandTClevels,butnotontheimprovementoftheIMT,TG,HDLandLp(a).ConclusionRs3798220polymorphismhasacertainimpactonthecurativeeffectsofstatin,onLDLandTClevels.

1WANG Zhi-xiao ZHAN Zhon-qun MAO Shan LI Yu HE Chao-rong WANG Chong-quan.Effects of MSCs on the progression of atherosclerosis plaque in ApoE-knockout miceA.心血管疾病,2012-03.
2Keng-Thye Woo;Yeow-Kok Lau;Yi Zhao;Fang-E Liu;Hwee-Boon Tan;Eng-Keng Tan;Fook-Chong Stephanie;Choong-Meng Chan;Kok-Seng Wong.Disease Progression, Response to ACEI/ATRA Therapy and Influence of ACE Gene in IgA Nephritis.免疫学,2007-03.
3Guozhong Zhang Lina Ning Sujuan Gao.Effects of acupuncture therapy on plasma neuropeptide Y levels and resuscitation in patients with very early stage acute cerebral infarction—A randomized controlled study.神经病学与精神病学,2009-02.
4.Effect of two intensive statin regimens on progression of coronary disease.心血管疾病,2011-04.
5Xinjing Lin;Changlin Hu;Yunlan Xie;Xin Zhang;Xiangping Liu;Ge Yan.Polymorphism of apolipoprotein E gene and post-stroke vascular dementia.神经病学与精神病学,2006-05.
6陈晓洁;梁清.Combined effects of headgroup charge and tail unsaturation of lipids on lateral organization and diffusion of lipids in model biomembranes.物理,2017-04.
7Sunyoung Park Soyoung Cheon Daeho Cho.The Dual Effects of Interleukin-18 in Tumor Progression.免疫学,2007-05.
8YANG Jin-ru;LI Fen;JIANG Jue.Effect of hormone therapy on carotid elasticity in postmenopausalwomen by Echo-tracking technique.心血管疾病,2011-01.
9.Interactions of the LIPG 584C>T polymorphism and alcoholconsumption on serum lipid levels.心血管疾病,2011-09.
10Li Kechun,Zhang Tao,Liu Gang,Jin Ping,Wang Yeqing,Wang Lijie,Xu Meixian,Liu Chunyi,Liu Yingchao,Zhou Tao,Xu Yan,Yang Ying,Fang Boliang,Yang Xin,Liu Chunfeng,Qian Suyun.Plasma exchange therapy for acute necrotizing encephalopathy of childhood.医药卫生,2021-08.

Effects of apolipoprotein A polymorphism on plasma levels of lipids, progression of carotid atherosclerosis and response to statin therapy

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