Protective effects of Rabdosia japonica var. glaucocalyx extract on lipopolysaccharide-induced acute lung injury in mice-中国Betway体育网页登陆

摘要 ThepresentstudywasdesignedtoevaluatetheprotectiveeffectsofethanolextractsofRabdosiajaponicavar.glaucocalyx(Maxim.)Hara(RJ)onlipopolysaccharide(LPS)-inducedacutelunginjury(ALI)inmiceandthepossibleunderlyingmechanismsofaction.ThemicewereorallyadministratedwithRJextract(16,32or64mg?kg–1)dailyforconsecutive7daysbeforeLPSchallenge.Theungspecimensandthebronchoalveolarlavagefluid(BALF)werecollectedforhistopathologicalexaminationsandbiochemicalanalyses.PretreatmentwithRJsignificantlyenhancedsuperoxidedismutase(SOD)activityandreducedthewet-to-dryweight(W/D)ratio,thelevelsofnitricoxide(NO)andproteinleakage,andmyeloperoxidase(MPO)activityinmicewithALI,inadose-dependentmanner.RJreducedcomplementdepositionandsignificantlyattenuatedLPS-inducedALIbyreducingproductionsofinflammatorymediators,suchastumornecrosisfactor-α(TNF-α),interleukin-6(IL-6),andinterleukin-1β(IL-1β).TheresultsdemonstratedthatRJmayattenuateLPS-inducedALIviareducingtheproductionofpro-inflammatorymediators,andreducingcomplementdepositionandradicals.

1孙海晨;钱晓明;聂时南;吴学豪.Serial analysis of gene expression in mice with lipopolysaccharide-induced acute lung injury.临床医学,2005-02.
2Zhang Cuiping;Li Xiaoyu;Jing Xue;Zhang Bo;Zhang Qi;Niu Qinghui;Wang Jianjun;Tian Zibin.Protective Effects of Oyster Extract Against Hepatic Tissue Injury in Alcoholic Liver Diseases.海洋科学,2014-02.
3Jin Can,Chen Jie,Gu Juan,Zhang Wei.Gut-lymph-lung pathway mediates sepsis-induced acute lung injury.医药卫生,2020-09.
4Gan Lu;Wang Zhenhua;Zhang Hong.3 - 85 Protective Effects of Shikonin on Brain Injury Induced by Carbon Ion Beam in Mouse.物理,2013-01.
5Hong Ping HE.Two New Diterpene Alkaloids from the Roots of Spiraea japonica var. acut.化学,2001-01.
6陶军;杨天德;陈祥瑞;黄河.Changes in liquid clearance of alveolar epithelium after oleic acid-induced acute lung injury in rats.临床医学,2004-02.
7Lei Jing,Wenhui Chen,Li Zhao,Lijuan Guo,Chaoyang Liang,Jingyu Chen,Chen Wang.Acute kidney injury following adult lung transplantation.医药卫生,2022-12.
8Li Hongyan;Zhang Hong;Yan Jiawei;Zhou Rong.3-63 Underlying Toxicological Mechanism Acute Injury Induced by Carbon Ion Radiation in Pubertal Mice Testes.物理,2015-01.
9Zhi-gao Sun;Li-ping Chen;Fa-wei Wang;Cheng-yong Xu;Miao Geng.Protective effects of ginsenoside Rg1 against hydrogen peroxide-induced injury in human neuroblastoma cells.神经病学与精神病学,2016-07.
10Hyung-Ho Lim Yun-kyung Song Oh-Bong Kwon.Protective effects of Singi-pill on Traumatic brain injury-induced apoptosis in Rat hippocampal dentate gyrus.中医骨伤科学,2007-01.

Protective effects of Rabdosia japonica var. glaucocalyx extract on lipopolysaccharide-induced acute lung injury in mice

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