Inhalation treatment of lung cancer： the influence of composition, size and shape of nanocarriers on their lung accumulation and retention-中国Betway体育网页登陆

摘要 Objective:Variousnanoparticleshavebeendesignedandtestedinordertoselectoptimalcarriersfortheinhalationdeliveryofanticancerdrugstothelungs.Methods:Thefollowingnanocarrierswerestudied:micelles,liposomes,mesoporoussilicananoparticles(MSNs),polypropyleneimine(PPI)dendrimer-siRNAcomplexesnanoparticles,quantumdots(QDs),andpoly(ethyleneglycol)polymers.Allparticleswerecharacterizedusingthefollowingmethods:dynamiclightscattering,zetapotential,atomicforcemicroscopy,invitrocyto-andgenotoxicity.Invivoorgandistributionofallnanoparticles,retentioninthelungs,andanticancereffectsofliposomesloadedwithdoxorubicinwereexaminedinnudemiceafterthepulmonaryorintravenousdelivery.Results:Significantdifferencesinlunguptakewerefoundaftertheinhalationdeliveryoflipid-basedandnon-lipid-basednanoparticles.Theaccumulationofliposomesandmicellesinlungsremainedrelativelyhigheven24hafterinhalationwhencomparedwithMSNs,QDs,andPPIdendrimers.Therewerenotabledifferencesbetweennanoparticleaccumulationinthelungsandotherorgans1and3hafterinhalationorintravenousadministrations,but24hafterintravenousinjectionallnanoparticlesweremainlyaccumulatedintheliver,kidneys,andspleen.Inhalationdeliveryofdoxorubicinbyliposomessignificantlyenhanceditsanticancereffectandpreventedsevereadversesideeffectsofthetreatmentinmicebearingtheorthotopicmodeloflungcancer.Conclusion:Theresultsofthestudydemonstratethatlipid-basednanocarriershadconsiderablyhigheraccumulationandlongerretentiontimeinthelungswhencomparedwithnon-lipid-basedcarriersaftertheinhalationdelivery.Theseparticlesaremostsuitableforeffectiveinhalationtreatmentoflungcancer.

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Inhalation treatment of lung cancer： the influence of composition, size and shape of nanocarriers on their lung accumulation and retention

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