A bystander cell-based GM-CSF secreting vaccine synergized with a low dose of cyclophosphamide presents therapeutic immune responses against murine hepatocellular carcinoma-中国Betway体育网页登陆

摘要 Granulocyte巨噬细胞刺激殖民地的因素(GM-CSF)secreting细胞的肿瘤疫苗在鼠科的模型和病人受不了癌症贡献有势力antitumor免疫者回答的正式就职。Hepatocellular癌(HCC)是在中国的最经常、恶意的癌症之一。第一次，我们描述释放向与这类癌症作斗争代表步的疫苗的策略的GM-CSF。在这研究，一个旁观者对鼠科的HCC的基于房间的GM-CSFsecreting疫苗，Hepa1-6/B78H1-GM-CSF，与cyclophosphamide(CY)的低剂量被共同管理。在与肿瘤和种痘质问以后，免疫学的试金证明细胞的antitumor免疫者回答高效地被激活并且肿瘤开发显著地被延迟，它依赖于有CY的协同作用。在鼠科的模型的anti-HCC疫苗的有希望的结果表明未来的可行性为在HCC病人的这治疗的临床的申请。

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A bystander cell-based GM-CSF secreting vaccine synergized with a low dose of cyclophosphamide presents therapeutic immune responses against murine hepatocellular carcinoma

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