摘要
Severalriskfactors,whichincludeheredity,ultra-violet(UV)lightandchronicinflammation,contributetopterygiumdevelopment.However,thereisnoreportintegratingthesefactorsinthepathogenesisofpterygium.Theaimofthisreviewistodescribetheconnectionbetweenheredity,UV,andinflammationinpterygiumdevelopment.ExistingreportsindicatethatsunlightexposureisthemainfactorinpterygiumoccurrencebyinducinggrowthfactorproductionorchronicinflammationorDNAdamage.Hereditymaybeafactor.Ourstudiesonfactorsinpterygiumoccurrenceandrecurrenceidentifythatheredityiscrucialforpterygiumtodevelop,andthatsunlightisonlyatrigger,andthatchronicinflammationpromotespterygiumenlargement.WeproposethatgeneticfactorsmayinterferewiththecontroloffibrovascularproliferationwhileUVlightor(sunlight)mostlikelyonlytriggerspterygiumdevelopmentbyinducinggrowthfactorswhichpromotevibrantfibrovascularproliferationinpredisposedindividuals.Italsojusttriggersinflammationandcollagenolysis,whichmaybepromotersoftheenlargementofthefibrovascularmass.Pterygiumprobablyoccursinthepresenceofexuberantcollagenproductionandprofuseneovascularisation.
出版日期
2014年03月13日（中国Betway体育网页登陆平台首次上网日期，不代表论文的发表时间）
